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PMID: 18035059 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Innexins form two types of channels.

FEBS letters ·Vol. 581 ·No. 29 ·2007-12-11 ·Pages 5703-8

Bao L, Samuels S, Locovei S, Macagno ER, Muller KJ, Dahl G

Abstract

Injury to the central nervous system triggers glial calcium waves in both vertebrates and invertebrates. In vertebrates the pannexin1 ATP-release channel appears to provide for calcium wave initiation and propagation. The innexins, which form invertebrate gap junctions and have sequence similarity with the pannexins, are candidates to form non-junctional membrane channels. Two leech innexins previously demonstrated in glia were expressed in frog oocytes. In addition to making gap junctions, innexins also formed non-junctional membrane channels with properties similar to those of pannexons. In addition, carbenoxolone reversibly blocked the loss of carboxyfluorescein dye into the bath from the giant glial cells in the connectives of the leech nerve cord, which are known to express the innexins we assayed.

MeSH Terms
Animals Calcium Signaling Connexins/physiology Cytoplasm/metabolism Gap Junctions/metabolism Leeches/metabolism Models, Biological Neuroglia/metabolism Oocytes/metabolism Patch-Clamp Techniques Xenopus/metabolism
Chemicals
Connexins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Bao Li
Department of Physiology and Biophysics, University of Miami, School of Medicine, Miami, FL 33136, USA.
Samuels Stuart
Locovei Silviu
Macagno Eduardo R
Muller Kenneth J
Dahl Gerhard
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Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
DOI
10.1016/j.febslet.2007.11.030
Published
2007-12-11
Epub
2007-00-21
Pages
5703-8
Language
English
Region
England
NLM ID
0155157
PMCID
PMC2489203
Subset
IM
Grants
NINDS NIH HHS · NS37025 · United States
NINDS NIH HHS · NS34927 · United States
NINDS NIH HHS · R01 NS037025 · United States
NIGMS NIH HHS · R01 GM048610-14 · United States
NIGMS NIH HHS · GM48610 · United States
NIGMS NIH HHS · R01 GM048610 · United States
NINDS NIH HHS · T32 NS007044 · United States
NINDS NIH HHS · R01 NS034927 · United States
NIGMS NIH HHS · R01 GM048610-13A2 · United States
External Links
PubMed source DOI: 10.1016/j.febslet.2007.11.030 PMC Full Text View journal details
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