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PMID: 18037899 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Multivalent engagement of chromatin modifications by linked binding modules.

Nature reviews. Molecular cell biology ·Vol. 8 ·No. 12 ·2007-12-00 ·Pages 983-94

Ruthenburg AJ, Li H, Patel DJ, Allis CD

Abstract

Various chemical modifications on histones and regions of associated DNA play crucial roles in genome management by binding specific factors that, in turn, serve to alter the structural properties of chromatin. These so-called effector proteins have typically been studied with the biochemist's paring knife--the capacity to recognize specific chromatin modifications has been mapped to an increasing number of domains that frequently appear in the nuclear subset of the proteome, often present in large, multisubunit complexes that bristle with modification-dependent binding potential. We propose that multivalent interactions on a single histone tail and beyond may have a significant, if not dominant, role in chromatin transactions.

MeSH Terms
Animals Chromatin/metabolism Chromatin Assembly and Disassembly Histone Code Histones/metabolism Humans
Chemicals
Chromatin Histones
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ruthenburg Alexander J
Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10065, USA. [email protected]
Li Haitao
Patel Dinshaw J
Allis C David
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2298
Email
[email protected]
Published
2007-12-00
Pages
983-94
Language
English
Region
England
NLM ID
100962782
PMCID
PMC4690530
Subset
IM
Grants
NCI NIH HHS · P30 CA008748 · United States
External Links
PubMed source DOI: 10.1038/nrm2298 PMC Full Text View journal details
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