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PMID: 180425 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Translation in vitro of vesicular stomatitis virus mRNA lacking 5'-terminal 7-methylguanosine.

Nature ·Vol. 262 ·No. 5563 ·1976-07-01 ·Pages 32-7

Rose JK, Lodish HF

Abstract

The 5'-terminus 7-methylguanosine of vesicular stomatitis virus mRNA is not essential for translation of the mRNA. The 7-methylguanosine seems to have a mediating rather than an obligatory role in ribosome binding by the mRNA and in mRNA translation.

MeSH Terms
Cell-Free System Guanine Nucleotides/metabolism Kinetics Peptide Chain Initiation, Translational Protein Biosynthesis RNA, Messenger/metabolism RNA, Viral/metabolism Ribosomes/metabolism Structure-Activity Relationship Vesicular stomatitis Indiana virus/metabolism
Chemicals
Guanine Nucleotides RNA, Messenger RNA, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rose J K
Lodish H F
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/262032a0
Published
1976-07-01
Pages
32-7
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/262032a0 View journal details
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