Induction of pluripotency: from mouse to human.

Cell ·Vol. 131 ·No. 5 ·2007-11-30 ·Pages 834-5

Zaehres H, Schöler HR

Abstract

In this issue of Cell, Takahashi et al. (2007) transfer their seminal work on somatic cell reprogramming from the mouse to human. By overexpressing the transcription factor quartet of Oct4, Sox2, Klf4, and c-Myc in adult human fibroblasts, they successfully isolate human pluripotent stem cells that resemble human embryonic stem cells by all measured criteria. This is a significant turning point in nuclear reprogramming research with broad implications for generating patient-specific pluripotent stem cells for research and therapeutic applications.

MeSH Terms

Animals Cellular Reprogramming/genetics,physiology Embryonic Stem Cells/physiology Genes, myc/physiology HMGB Proteins/genetics,physiology Humans Kruppel-Like Factor 4 Kruppel-Like Transcription Factors/genetics,physiology Mice Models, Biological Octamer Transcription Factor-3/genetics,physiology Pluripotent Stem Cells/metabolism,physiology SOXB1 Transcription Factors Transcription Factors/genetics,physiology

Chemicals

HMGB Proteins KLF4 protein, human Klf4 protein, mouse Kruppel-Like Factor 4 Kruppel-Like Transcription Factors Octamer Transcription Factor-3 SOX2 protein, human SOXB1 Transcription Factors Sox2 protein, mouse Transcription Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Zaehres Holm

Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Münster, NRW 48149, Germany.

Schöler Hans R

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2007.11.020

Published

2007-11-30

Pages

834-5

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

CommentOn

PMID: 18035408

External Links

PubMed source DOI: 10.1016/j.cell.2007.11.020 View journal details

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Induction of pluripotency: from mouse to human.

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