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PMID: 18054906 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population.

Environmental research ·Vol. 106 ·No. 2 ·2008-02-00 ·Pages 226-39

Goncharov A, Haase RF, Santiago-Rivera A, Morse G, Akwesasne Task Force on the Environment, McCaffrey RJ, Rej R, Carpenter DO

Abstract

We have investigated the relationships among the concentration of total serum polychlorinated biphenyls (PCBs), various PCB congener groupings, and three pesticides to total serum lipids in humans with and without self-reported cardiovascular disease. Blood samples were obtained from 335 adult Akwesasne Mohawks, and were analyzed for 101 PCB congeners, mirex, dichloro-diphenyl-dichloro-ethylene (DDE), and hexachlorobenzene (HCB), as well as serum triglycerides and cholesterol. Structural equation modeling, following the definition of latent variables by means of confirmatory factor analysis, was used to analyze the relationships between serum lipids with PCBs and heart disease. There were significant associations among PCBs, lipids, age, and body mass index (BMI), a fact which justified the application of the structural equation model. Gender of the participant was unrelated to any of the remaining study variables. The results of this study are consistent with a model in which age is considered as both an exogenous explanatory variable and a biological driving mechanism for the acquisition of PCBs. Moreover, the results of this study are consistent with the conclusion that PCBs, acting through P450 enzymes, are directly responsible for increased synthesis of cholesterol and triglycerides, substances known to be major risk factors for cardiovascular disease.

MeSH Terms
Adolescent Adult Aged Aged, 80 and over Cardiovascular Diseases/blood,epidemiology,ethnology,etiology Cholesterol/blood Environmental Exposure/adverse effects Environmental Monitoring Environmental Pollutants/blood Epidemiological Monitoring Female Humans Indians, North American/statistics & numerical data Male Middle Aged New York/epidemiology Pesticides/blood Polychlorinated Biphenyls/blood Regression Analysis Triglycerides/blood
Chemicals
Environmental Pollutants Pesticides Triglycerides Cholesterol Polychlorinated Biphenyls
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Goncharov Alexey
Institute for Health and the Environment, University at Albany, 5 University Place, A217, Rensselaer, NY 12144-3429, USA.
Haase Richard F
Santiago-Rivera Azara
Morse Gayle
Akwesasne Task Force on the Environment
McCaffrey Robert J
Rej Robert
Carpenter David O
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Article Info
Journal
Environmental research
Abbr.
Environ Res
ISSN
0013-9351
DOI
10.1016/j.envres.2007.10.006
Published
2008-02-00
Epub
2007-00-04
Pages
226-39
Language
English
Region
Netherlands
NLM ID
0147621
PMCID
PMC2258089
Subset
IM
Grants
FIC NIH HHS · D43 TW000636 · United States
NIEHS NIH HHS · P42 ES004913-10 · United States
NIEHS NIH HHS · ES04913 · United States
FIC NIH HHS · TW00636 · United States
External Links
PubMed source DOI: 10.1016/j.envres.2007.10.006 PMC Full Text View journal details
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