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PMID: 18065468 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

How does intracellular Ca2+ oscillate: by chance or by the clock?

Biophysical journal ·Vol. 94 ·No. 6 ·2008-03-15 ·Pages 2404-11

Skupin A, Kettenmann H, Winkler U, Wartenberg M, Sauer H, Tovey SC, Taylor CW, Falcke M

Abstract

Ca2+ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that Ca2+ oscillations are instead a sequence of random spikes. The standard deviation of the interspike intervals (ISIs) of individual spike trains is similar to the average ISI; it increases approximately linearly with the average ISI; and consecutive ISIs are uncorrelated. Decreasing the effective diffusion coefficient of free Ca2+ using Ca2+ buffers increases the average ISI and the standard deviation in agreement with the idea that individual spikes are caused by random wave nucleation. Array-enhanced coherence resonance leads to regular Ca2+ oscillations with small standard deviation of ISIs.

MeSH Terms
Action Potentials Animals Biophysics/methods Calcium/metabolism Calcium Signaling Cell Membrane/metabolism Diffusion Electrophysiology/methods Humans Models, Biological Neurons Oscillometry Stochastic Processes
Chemicals
Calcium
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Skupin Alexander
Department of Theoretical Physics, Hahn Meitner Institut, Berlin, Germany.
Kettenmann Helmut
Winkler Ulrike
Wartenberg Maria
Sauer Heinrich
Tovey Stephen C
Taylor Colin W
Falcke Martin
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
1542-0086
DOI
10.1529/biophysj.107.119495
Published
2008-03-15
Epub
2007-00-07
Pages
2404-11
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC2257893
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1529/biophysj.107.119495 PMC Full Text View journal details
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