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PMID: 18071 Published · ppublish English Clinical Trial Comparative Study Controlled Clinical Trial Journal Article

Intramuscular lorazepam versus pentobarbital premedication: a comparison of patient sedation, anxiolysis, and recall.

Anesthesia and analgesia ·Vol. 56 ·No. 4 ·1977-00-00 ·Pages 489-92

Aleniewski MI, Bulas BJ, Maderazo L, Mendoza C

Abstract

In a double-blind, controlled study in 40 veterans, IM lorazepam was significantly superior to IM pentobarbital as a preoperative sedative and in ability to suppress the memory of events of the operative day. A trend was noted (not statistically in this small series) toward greater patient acceptance of lorazepam. No important adverse effects or changes in vital signs occurred with either agent.

MeSH Terms

Adult Anti-Anxiety Agents/pharmacology Clinical Trials as Topic Double-Blind Method Evaluation Studies as Topic Female Humans Injections, Intramuscular Lorazepam/administration & dosage,pharmacology Male Memory/drug effects Mental Recall/drug effects Middle Aged Pentobarbital/administration & dosage,pharmacology Preanesthetic Medication Surgical Procedures, Operative

Chemicals

Anti-Anxiety Agents Pentobarbital Lorazepam

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Aleniewski M I

Bulas B J

Maderazo L

Mendoza C

Article Info

Journal

Anesthesia and analgesia

Abbr.

Anesth Analg

ISSN

0003-2999

DOI

10.1213/00000539-197707000-00005

Published

1977-00-00

Pages

489-92

Language

English

Region

United States

NLM ID

1310650

Subset

External Links

PubMed source DOI: 10.1213/00000539-197707000-00005 View journal details

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Intramuscular lorazepam versus pentobarbital premedication: a comparison of patient sedation, anxiolysis, and recall.

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