The role of the wax of the tubercle bacillus in establishing delayed hypersensitivity, hypersensitivity to a protein antigen, egg albumin.
Guinea pigs sensitized with egg albumin along with the purified wax fraction of the human tubercle bacillus respond with delayed hypersensitive reactivity to the protein antigen. Previous publications have reported a similar activity of the wax with respect to tuberculoprotein and picryl chloride. The effect is not referable to an ordinary adjuvant activity of the bacillary wax, since antibody titers are not increased in animals which receive it, and since a known adjuvant, water-in-oil emulsion, has no effect with respect to the induction of delayed hypersensitivity. This report further extends the rôle of the tubercle bacillary wax in the induction of delayed hypersensitive states.
8 references, click to expand
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Corneal Reactions of Normal and of Tuberculous Guinea Pigs to Tuberculo-Protein and Tuberculo-Phosphatide.Am J Pathol. 1935 Nov;11(6):937-952.3 PMID: 19970242
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TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : II. REACTIONS OF TISSUES FROM GUINEA PIGS INFECTED WITH GROUP C HEMOLYTIC STREPTOCOCCI.J Exp Med. 1936 Aug 31;64(3):355-68 PMID: 19870540
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TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : I. TUBERCULIN SENSITIVE TISSUES.J Exp Med. 1936 Aug 31;64(3):339-53 PMID: 19870539
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THE SPECIFIC CYTOTOXIC ACTION OF TUBERCULIN IN TISSUE CULTURE.J Exp Med. 1931 Jul 31;54(3):387-97 PMID: 19869925
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CELLULAR REACTIONS TO WAX-LIKE MATERIALS FROM ACID-FAST BACTERIA : THE UNSAPONIFIABLE FRACTION FROM THE TUBERCLE BACILLUS, STRAIN H-37.J Exp Med. 1935 Nov 30;62(6):751-69 PMID: 19870446
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REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : I. GENERAL TUBERCULIN-LIKE HYPERSENSITIVENESS, ALLERGY, OR HYPERERGY FOLLOWING THE SECONDARY REACTION.J Exp Med. 1929 Mar 31;49(4):615-36 PMID: 19869568
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STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : VII. SKIN SENSITIZATION BY INTRAPERITONEAL INJECTIONS.J Exp Med. 1940 Jan 31;71(2):237-45 PMID: 19870959
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The role of the wax of the tubercle bacillus in establishing delayed hypersensitivity; hypersensitivity to a simple chemical substance, picryl chloride.J Exp Med. 1948 Oct 1;88(4):485-502 PMID: 18884905
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