Abstract
Mutations in the gene encoding beta-glucocerebrosidase, a lysosomal degrading enzyme, have recently been associated with the development of Parkinson disease. Here we report the results found in a cohort of Portuguese Parkinson disease patients and healthy age-matched controls for mutations in the aforementioned gene. This screening was accomplished by sequencing the complete open-reading frame, as well as intron/exon boundaries, of the glucocerebrosidase gene, in a total of 230 patients and 430 controls. We have found an increased number of Parkinson disease patients presenting mutations in GBA when compared to controls. These results, together with recent literature, clearly suggest a role of glucocerebrosidase in the development of Parkinson disease.
MeSH Terms
Brain/enzymology,physiopathology
Case-Control Studies
Cohort Studies
DNA Mutational Analysis
Gene Expression Regulation, Enzymologic/genetics
Gene Frequency/genetics
Genetic Markers/genetics
Genetic Predisposition to Disease/genetics
Genetic Testing
Genotype
Glucosylceramidase/genetics
Humans
Mutation/genetics
Open Reading Frames
Parkinson Disease/diagnosis,enzymology,genetics
Polymorphism, Genetic/genetics
Portugal
Chemicals
Genetic Markers
Glucosylceramidase
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Bras Jose
Laboratory of Neurogenetics, National Institutes on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Paisan-Ruiz Coro
Guerreiro Rita
Ribeiro Maria Helena
Morgadinho Ana
Januario Cristina
Sidransky Ellen
Oliveira Catarina
Singleton Andrew
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