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PMID: 18160539 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Review

A2A receptors in inflammation and injury: lessons learned from transgenic animals.

Journal of leukocyte biology ·Vol. 83 ·No. 3 ·2008-03-00 ·Pages 447-55

Haskó G, Pacher P

Abstract

Adenosine regulates the function of the innate and adaptive immune systems through targeting virtually every cell type that is involved in orchestrating an immune/inflammatory response. Of the four adenosine receptors (A(1), A(2A), A(2B), A(3)), A(2A) receptors have taken center stage as the primary anti-inflammatory effectors of extracellular adenosine. This broad, anti-inflammatory effect of A(2A) receptor activation is a result of the predominant expression of A(2A) receptors on monocytes/macrophages, dendritic cells, mast cells, neutrophils, endothelial cells, eosinophils, epithelial cells, as well as lymphocytes, NK cells, and NKT cells. A(2A) receptor activation inhibits early and late events occurring during an immune response, which include antigen presentation, costimulation, immune cell trafficking, immune cell proliferation, proinflammatory cytokine production, and cytotoxicity. In addition to limiting inflammation, A(2A) receptors participate in tissue remodeling and reparation. Consistent with their multifaceted, immunoregulatory action on immune cells, A(2A) receptors have been shown to impact the course of a wide spectrum of ischemic, autoimmune, infectious, and allergic diseases. Here, we review the regulatory roles of A(2A) receptors in immune/inflammatory diseases of various organs, including heart, lung, gut, liver, kidney, joints, and brain, as well as the role of A(2A) receptors in regulating multiple organ failure and sepsis.

MeSH Terms
Adenosine/physiology Animals Animals, Genetically Modified Humans Immunity Inflammation/physiopathology Models, Biological Receptors, Adenosine A2/immunology,physiology Receptors, Purinergic P1/physiology Signal Transduction Wounds and Injuries/physiopathology
Chemicals
Receptors, Adenosine A2 Receptors, Purinergic P1 Adenosine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Haskó György
UMDNJ-New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA. [email protected]
Pacher Pál
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Article Info
Journal
Journal of leukocyte biology
Abbr.
J Leukoc Biol
ISSN
0741-5400
DOI
10.1189/jlb.0607359
Email
[email protected]
Published
2008-03-00
Epub
2007-00-26
Pages
447-55
Language
English
Region
United States
NLM ID
8405628
PMCID
PMC2268631
Subset
IM
Grants
NIGMS NIH HHS · R01 GM 66189 · United States
NIGMS NIH HHS · R01 GM066189-02 · United States
NIGMS NIH HHS · R01 GM066189 · United States
Intramural NIH HHS · Z01 AA000375-02 · United States
NIGMS NIH HHS · R01 GM066189-01 · United States
External Links
PubMed source DOI: 10.1189/jlb.0607359 PMC Full Text View journal details
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