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PMID: 18163994 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Influence of polymorphism of glutathione S-transferase T1 on Chinese infertile patients with varicocele.

Fertility and sterility ·Vol. 91 ·No. 3 ·2009-03-00 ·Pages 960-2

Wu Q, Xing J, Xue W, Sun J, Wang X, Jin X

Abstract

To investigate the influence of glutathione S-transferase T1 (GSTT1) gene polymorphism on Chinese infertile patients with varicocele, 63 infertile patients with varicocele and 54 healthy fertile controls were recruited in this case-control study. Our results show that oxidative damage may be the cause of infertility in patients with varicocele, and GSTT1 null genotype predisposes to over oxidative damage to spermatocytes of infertile patients with varicocele.

MeSH Terms
Antioxidants/analysis Asians/genetics Biomarkers/analysis Case-Control Studies DNA Damage DNA, Mitochondrial/analysis Gene Deletion Genetic Predisposition to Disease Glutathione Transferase/genetics Humans Infertility, Male/enzymology,ethnology,genetics Male Malondialdehyde/analysis Nitric Oxide/analysis Odds Ratio Oxidative Stress/genetics Phenotype Polymorphism, Genetic Risk Assessment Semen/chemistry Varicocele/complications,enzymology,ethnology,genetics
Chemicals
Antioxidants Biomarkers DNA, Mitochondrial Nitric Oxide Malondialdehyde glutathione S-transferase T1 Glutathione Transferase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Wu Qifei
Department of Urology, First Affiliated Hospital, School of Medicine, Xi'an Jiao Tong University, Xi'an City, ShannXi Province, People's Republic of China.
Xing Junping
Xue Wei
Sun Jianhua
Wang Xinyang
Jin Xiaojuan
Article Info
Journal
Fertility and sterility
Abbr.
Fertil Steril
ISSN
1556-5653
DOI
10.1016/j.fertnstert.2007.08.061
Published
2009-03-00
Epub
2007-00-27
Pages
960-2
Language
English
Region
United States
NLM ID
0372772
Subset
IM
External Links
PubMed source DOI: 10.1016/j.fertnstert.2007.08.061 View journal details
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