Dopamine-sensitive adenylate cyclase occurs in a region of substantia nigra containing dopaminergic dendrites.

Science (New York, N.Y.) ·Vol. 193 ·No. 4254 ·1976-08-20 ·Pages 683-5

Kebabian JW, Saavedra JM

Abstract

The zona reticulata, the subdivision of the substantia nigra containing dendrites of the dopaminergic nigro-neostriatal neurons, contains dopamine-sensitive adenylate cyclase activity. This nigral dopamine receptor is similar to the striatal dopamine receptor. These and previous data suggest a physiological role (or roles) for dopamine in the substantia nigra.

MeSH Terms

Adenylyl Cyclases/metabolism Animals Chlorpromazine/pharmacology Dendrites/metabolism Dopamine/metabolism Dopamine Antagonists Enzyme Activation Hydroxydopamines/pharmacology Isoproterenol/metabolism Norepinephrine/metabolism Rats Receptors, Neurotransmitter/metabolism Substantia Nigra/drug effects,enzymology,metabolism

Chemicals

Dopamine Antagonists Hydroxydopamines Receptors, Neurotransmitter Adenylyl Cyclases Isoproterenol Chlorpromazine Dopamine Norepinephrine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kebabian J W

Saavedra J M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.181842

Published

1976-08-20

Pages

683-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.181842 View journal details

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Dopamine-sensitive adenylate cyclase occurs in a region of substantia nigra containing dopaminergic dendrites.

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