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PMID: 18202389 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Molecular population genetics of Drosophila subtelomeric DNA.

Genetics ·Vol. 178 ·No. 1 ·2008-01-00 ·Pages 477-87

Anderson JA, Song YS, Langley CH

Abstract

DNA sequence surveys in yeast and humans suggest that the forces shaping telomeric polymorphism and divergence are distinctly more dynamic than those in the euchromatic, gene-rich regions of the chromosomes. However, the generality of this pattern across outbreeding, multicellular eukaryotes has not been determined. To characterize the structure and evolution of Drosophila telomeres, we collected and analyzed molecular population genetics data from the X chromosome subtelomere in 58 lines of North American Drosophila melanogaster and 29 lines of African D. melanogaster. We found that Drosophila subtelomeres exhibit high levels of both structural and substitutional polymorphism relative to linked euchromatic regions. We also observed strikingly different patterns of variation in the North American and African samples. Moreover, our analyses of the polymorphism data identify a localized hotspot of recombination in the most-distal portion of the X subtelomere. While the levels of polymorphism decline sharply and in parallel with rates of crossing over per physical length over the distal first euchromatic megabase pairs of the X chromosome, our data suggest that they rise again sharply in the subtelomeric region (approximately 80 kbp). These patterns of historical recombination and geographic differentiation indicate that, similar to yeast and humans, Drosophila subtelomeric DNA is evolving very differently from euchromatic DNA.

MeSH Terms
Africa Animals Chromosomes/genetics Crossing Over, Genetic DNA/genetics Drosophila melanogaster/classification,genetics Molecular Sequence Data North America Polymorphism, Single Nucleotide/genetics Population Dynamics Telomere/genetics
Chemicals
DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Anderson Jennifer A
Section of Evolution and Ecology, University of California, Davis 95616, USA. [email protected]
Song Yun S
Langley Charles H
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.107.083196
Email
[email protected]
Published
2008-01-00
Pages
477-87
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC2206096
Subset
IM
Grants
NIGMS NIH HHS · K99 GM080099 · United States
NHGRI NIH HHS · R01 HG002942 · United States
NHGRI NIH HHS · R01-HG002942 · United States
NIGMS NIH HHS · 1K99-GM080099 · United States
Databases
GENBANK
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PubMed source DOI: 10.1534/genetics.107.083196 PMC Full Text View journal details
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