Home LiteratureArticle Details
PMID: 1823620 Published · ppublish English Journal Article Review

Glycosylation in parasitic protozoa of the trypanosomatidae family.

Glycoconjugate journal ·Vol. 8 ·No. 6 ·1991-12-00 ·Pages 443-7

Zamze S

Abstract

Over the last few years enormous interest has been shown in the structures of the glycan moieties of various parasite surface glycoconjugates. Structures have been determined for the glyco-components of glycosylphosphatidylinositol (GPI) protein membrane anchors, for asparagine-linked oligosaccharides, and for the glycans of complex glycolipids. The following attempts to illustrate a few of the most salient observations with regard to the structures and possible functions of parasite surface glycans.

MeSH Terms
Animals Glycolipids/analysis Glycosylation Leishmania/chemistry Trypanosoma/metabolism
Chemicals
Glycolipids
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Zamze S
Department of Biochemistry, University of Oxford, UK.
References (45)
45 references, click to expand
  1. Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major.
    Mol Biochem Parasitol. 1990 May;40(2):255-67 PMID: 2362605
  2. Expression of a stage-specific lipophosphoglycan in Leishmania major amastigotes.
    Mol Biochem Parasitol. 1991 Mar;45(1):91-9 PMID: 1646960
  3. Structure of the lipophosphoglycan from Leishmania major.
    J Biol Chem. 1990 Nov 15;265(32):19611-23 PMID: 2246247
  4. A family of glycoinositol phospholipids from Leishmania major. Isolation, characterization, and antigenicity.
    J Biol Chem. 1989 Jan 15;264(2):757-66 PMID: 2910865
  5. Structure of the phosphosaccharide-inositol core of the Leishmania donovani lipophosphoglycan.
    J Biol Chem. 1989 Apr 25;264(12):6711-5 PMID: 2708338
  6. Requirement of lipophosphoglycan for intracellular survival of Leishmania donovani within human monocytes.
    J Immunol. 1990 Apr 1;144(7):2745-50 PMID: 2319134
  7. Surface carbohydrates of procyclic forms of African trypanosomes studied using fluorescence activated cell sorter analysis and agglutination with lectins.
    Mol Biochem Parasitol. 1987 Mar;23(2):165-72 PMID: 3106807
  8. Expression of LPG and GP63 by different developmental stages of Leishmania major in the sandfly Phlebotomus papatasi.
    Parasitology. 1990 Dec;101 Pt 3:337-43 PMID: 2092290
  9. Characterization of dolichol diphosphate oligosaccharide: protein oligosaccharyltransferase and glycoprotein-processing glucosidases occurring in trypanosomatid protozoa.
    J Biol Chem. 1988 Nov 25;263(33):17360-5 PMID: 3053710
  10. Acid protease activity of a major surface membrane glycoprotein (gp63) from Leishmania mexicana promastigotes.
    Mol Biochem Parasitol. 1988 Jan 1;27(1):43-52 PMID: 3278222
  11. Serum resistance of metacyclic stage Leishmania major promastigotes is due to release of C5b-9.
    J Immunol. 1990 Dec 15;145(12):4311-6 PMID: 2147941
  12. The N-linked carbohydrate chain of the 85-kilodalton glycoprotein from Trypanosoma cruzi trypomastigotes contains sialyl, fucosyl and galactosyl (alpha 1-3)galactose units.
    Mol Biochem Parasitol. 1990 Feb;39(1):101-7 PMID: 2106074
  13. Structures of the glycoinositolphospholipids from Leishmania major. A family of novel galactofuranose-containing glycolipids.
    J Biol Chem. 1990 May 5;265(13):7385-94 PMID: 2139661
  14. Evidence for concanavalin A binding sites on the surface coat of Trypanosoma congolense.
    Parasitology. 1980 Feb;80(1):113-22 PMID: 7383705
  15. Role of carbohydrates within variant surface glycoprotein of Trypanosoma congolense. Protection against proteolytic attack.
    Eur J Biochem. 1985 Sep 2;151(2):385-91 PMID: 3896788
  16. Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.
    J Immunol. 1985 Jul;135(1):564-9 PMID: 2582050
  17. Serological activity against galactosyl-alpha(1-3)galactose in sera from patients with several kinetoplastida infections.
    J Clin Microbiol. 1988 Jan;26(1):126-32 PMID: 2449451
  18. Synthesis of dolichol derivatives and protein glycosylation in trypanosomatids.
    Biochem Soc Trans. 1988 Jun;16(3):268-71 PMID: 3141228
  19. Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids.
    J Biol Chem. 1991 Aug 15;266(23):15170-9 PMID: 1831200
  20. Structure, biosynthesis, and function of glycosylphosphatidylinositols.
    Biochemistry. 1990 Jun 12;29(23):5413-22 PMID: 2143679
  21. An antigenically distinct lipophosphoglycan on amastigotes of Leishmania major.
    Mol Biochem Parasitol. 1991 Apr;45(2):337-44 PMID: 1710036
  22. Structure of the major carbohydrate fragment of the Leishmania donovani lipophosphoglycan.
    Biochemistry. 1987 Sep 22;26(19):6233-8 PMID: 3689770
  23. Structural characterization of the asparagine-linked oligosaccharides from Trypanosoma brucei type II and type III variant surface glycoproteins.
    J Biol Chem. 1991 Oct 25;266(30):20244-61 PMID: 1939085
  24. Biosynthesis of Trypanosoma brucei variant surface glycoproteins. N-glycosylation and addition of a phosphatidylinositol membrane anchor.
    J Biol Chem. 1986 Jan 5;261(1):356-62 PMID: 2934386
  25. Characterisation of the asparagine-linked oligosaccharides from Trypanosoma brucei type-I variant surface glycoproteins.
    Eur J Biochem. 1990 Feb 14;187(3):657-63 PMID: 2303059
  26. Leishmania and the macrophage: a marriage of inconvenience.
    Immunol Today. 1989 Oct;10(10):328-33 PMID: 2679629
  27. The glycoinositolphospholipid profiles of two Leishmania major strains that differ in lipophosphoglycan expression.
    Mol Biochem Parasitol. 1990 Jan 1;38(1):57-67 PMID: 2157154
  28. Developmental variation of glycosylphosphatidylinositol membrane anchors in Trypanosoma brucei. Identification of a candidate biosynthetic precursor of the glycosylphosphatidylinositol anchor of the major procyclic stage surface glycoprotein.
    J Biol Chem. 1991 May 5;266(13):8392-400 PMID: 1850744
  29. Lipophosphoglycan of Leishmania major that vaccinates against cutaneous leishmaniasis contains an alkylglycerophosphoinositol lipid anchor.
    Proc Natl Acad Sci U S A. 1987 Dec;84(24):8941-5 PMID: 3480520
  30. The generation of infective stage Leishmania major promastigotes is associated with the cell-surface expression and release of a developmentally regulated glycolipid.
    J Immunol. 1987 Nov 1;139(9):3099-106 PMID: 3312412
  31. Structure of the glycosyl-phosphatidylinositol membrane anchor of the Leishmania major promastigote surface protease.
    J Biol Chem. 1990 Oct 5;265(28):16955-64 PMID: 2145267
  32. Effect of tunicamycin on the extracellular acid phosphatase of Leishmania donovani promastigotes.
    Mol Biochem Parasitol. 1987 Jan 2;22(1):19-28 PMID: 3543672
  33. [Affinity of concanavalin A for "trypanosoma equiperdum": purification of the antigenic type specific glycoprotein fraction (author's transl)].
    Ann Immunol (Paris). 1976 Sep-Oct;127(5):761-74 PMID: 62551
  34. Trypanosoma brucei: effect of inhibition of N-linked glycosylation of the nearest neighbor analysis of the major variable surface coat glycoprotein.
    Mol Biochem Parasitol. 1982 Feb;5(2):117-31 PMID: 7078577
  35. The effect of swainsonine on the association of Trypanosoma cruzi with host cells.
    Mol Biochem Parasitol. 1985 Jun;16(1):1-10 PMID: 3929083
  36. N-linked high mannose-type oligosaccharides in the protozoa Crithidia fasciculata and Crithidia harmosa contain galactofuranose residues.
    J Biol Chem. 1986 Feb 15;261(5):2129-33 PMID: 3944129
  37. The leishmanial lipophosphoglycan: a multifunctional molecule.
    Exp Parasitol. 1990 Feb;70(2):241-5 PMID: 2404784
  38. Structures of the N-linked oligosaccharides of Gp63, the major surface glycoprotein, from Leishmania mexicana amazonensis.
    J Biol Chem. 1990 Jul 25;265(21):12240-7 PMID: 2373691
  39. Developmental modification of the lipophosphoglycan from Leishmania major promastigotes during metacyclogenesis.
    Mol Biochem Parasitol. 1990 Sep-Oct;42(2):225-33 PMID: 2176718
  40. Glucosylation of glycoproteins by mammalian, plant, fungal, and trypanosomatid protozoa microsomal membranes.
    Biochemistry. 1989 Oct 3;28(20):8108-16 PMID: 2532539
  41. Role of membrane N-linked oligosaccharides in host cell interaction with invasive forms of Trypanosoma cruzi.
    Mol Biochem Parasitol. 1987 Jan 15;22(2-3):109-14 PMID: 3553930
  42. Structural analysis of glycosyl-phosphatidylinositol antigens of Leishmania major.
    J Biol Chem. 1989 Jun 25;264(18):10457-63 PMID: 2525125
  43. Biosynthesis of a variant surface glycoprotein of Trypanosoma brucei. Processing of the glycolipid membrane anchor and N-linked oligosaccharides.
    J Biol Chem. 1988 Nov 25;263(33):17697-705 PMID: 3182868
  44. Structural characterization of several galactofuranose-containing, high-mannose-type oligosaccharides present in glycoproteins of the trypanosomatid Leptomonas samueli.
    Biochemistry. 1988 Mar 8;27(5):1543-9 PMID: 3130098
  45. Antigenic variation in trypanosomes.
    Proc R Soc Lond B Biol Sci. 1978 Jun 5;202(1146):55-72 PMID: 27816
Article Info
Journal
Glycoconjugate journal
Abbr.
Glycoconj J
ISSN
0282-0080
DOI
10.1007/BF00769843
Published
1991-12-00
Pages
443-7
Language
English
Region
United States
NLM ID
8603310
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00769843 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2