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PMID: 18239643 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural

Genes implicated in serotonergic and dopaminergic functioning predict BMI categories.

Obesity (Silver Spring, Md.) ·Vol. 16 ·No. 2 ·2008-02-00 ·Pages 348-55

Fuemmeler BF, Agurs-Collins TD, McClernon FJ, Kollins SH, Kail ME, Bergen AW, Ashley-Koch AE

Abstract

This study addressed the hypothesis that variation in genes associated with dopamine function (SLC6A3, DRD2, DRD4), serotonin function (SLC6A4, and regulation of monoamine levels (MAOA) may be predictive of BMI categories (obese and overweight + obese) in young adulthood and of changes in BMI as adolescents transition into young adulthood. Interactions with gender and race/ethnicity were also examined. Participants were a subsample of individuals from the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative sample of adolescents followed from 1995 to 2002. The sample analyzed included a subset of 1,584 unrelated individuals with genotype data. Multiple logistic regressions were conducted to evaluate the associations between genotypes and obesity (BMI > 29.9) or overweight + obese combined (BMI > or = 25) with normal weight (BMI = 18.5-24.9) as a referent. Linear regression models were used to examine change in BMI from adolescence to young adulthood. Significant associations were found between SLC6A4 5HTTLPR and categories of BMI, and between MAOA promoter variable number tandem repeat (VNTR) among men and categories of BMI. Stratified analyses revealed that the association between these two genes and excess BMI was significant for men overall and for white and Hispanic men specifically. Linear regression models indicated a significant effect of SLC6A4 5HTTLPR on change in BMI from adolescence to young adulthood. Our findings lend further support to the involvement of genes implicated in dopamine and serotonin regulation on energy balance.

MeSH Terms
Adolescent Adult Aging/ethnology,genetics,metabolism Body Mass Index Cohort Studies Dopamine/metabolism Dopamine Plasma Membrane Transport Proteins/genetics,metabolism Energy Metabolism/genetics,physiology Female Hispanic or Latino Humans Logistic Models Longitudinal Studies Male Monoamine Oxidase/genetics,metabolism Obesity/ethnology,genetics,physiopathology Predictive Value of Tests Receptors, Dopamine D4/genetics,metabolism Serotonin/metabolism Serotonin Plasma Membrane Transport Proteins/genetics,metabolism Sex Characteristics Whites
Chemicals
DRD4 protein, human Dopamine Plasma Membrane Transport Proteins SLC6A3 protein, human SLC6A4 protein, human Serotonin Plasma Membrane Transport Proteins Receptors, Dopamine D4 Serotonin Monoamine Oxidase Dopamine
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Fuemmeler Bernard F
Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA. [email protected]
Agurs-Collins Tanya D
McClernon F Joseph
Kollins Scott H
Kail Melanie E
Bergen Andrew W
Ashley-Koch Allison E
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Article Info
Journal
Obesity (Silver Spring, Md.)
Abbr.
Obesity (Silver Spring)
ISSN
1930-7381
DOI
10.1038/oby.2007.65
Email
[email protected]
Published
2008-02-00
Pages
348-55
Language
English
Region
United States
NLM ID
101264860
PMCID
PMC2919156
Subset
IM
Grants
NINDS NIH HHS · R01 NS049067 · United States
NICHD NIH HHS · P01 HD031921 · United States
NCI NIH HHS · K07 CA124905-01A1 · United States
NIDA NIH HHS · K23 DA017261 · United States
NCI NIH HHS · K07 CA124905 · United States
NIDA NIH HHS · K23 DA 017261 · United States
NINDS NIH HHS · NS 049067 · United States
NICHD NIH HHS · P01 HD 31921 · United States
External Links
PubMed source DOI: 10.1038/oby.2007.65 PMC Full Text View journal details
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