Facultative endocrine progenitor cells in the adult pancreas.

Cell ·Vol. 132 ·No. 2 ·2008-01-25 ·Pages 183-4

Dor Y, Melton DA

Abstract

Using a unique injury model of the pancreas in mouse, Xu et al. (2008) now reveal the involvement of neurogenin3, a marker for embryonic-type endocrine progenitor cells, in the formation of new insulin-producing beta cells. These neurogenin3-positive facultative endocrine progenitor cells in the adult pancreas may be of potential value for treating diabetes.

MeSH Terms

Animals Basic Helix-Loop-Helix Transcription Factors/genetics,metabolism Biomarkers Cell Differentiation Cell Proliferation Gene Expression Glucose/metabolism Green Fluorescent Proteins/metabolism Immunohistochemistry Insulin-Secreting Cells/cytology,metabolism Ligation Mice Mice, Knockout Mice, Transgenic Nerve Tissue Proteins/genetics,metabolism Organ Culture Techniques Pancreas/cytology,injuries Pancreatic Ducts/surgery RNA, Messenger/analysis,metabolism Stem Cells/cytology Time Factors beta-Galactosidase/metabolism

Chemicals

Basic Helix-Loop-Helix Transcription Factors Biomarkers Nerve Tissue Proteins Neurog3 protein, mouse RNA, Messenger Green Fluorescent Proteins beta-Galactosidase Glucose

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Dor Yuval

Department of Cellular Biochemistry and Human Genetics, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. [email protected]

Melton Douglas A

Article Info

Journal

Cell

Abbr.

Cell

ISSN

1097-4172

DOI

10.1016/j.cell.2008.01.004

[email protected]

Published

2008-01-25

Pages

183-4

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

CommentOn

PMID: 18243096

External Links

PubMed source DOI: 10.1016/j.cell.2008.01.004 View journal details

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Facultative endocrine progenitor cells in the adult pancreas.

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