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PMID: 18245821 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Evidence of spatially varying selection acting on four chromatin-remodeling loci in Drosophila melanogaster.

Genetics ·Vol. 179 ·No. 1 ·2008-05-00 ·Pages 475-85

Levine MT, Begun DJ

Abstract

The packaging of DNA into proper chromatin structure contributes to transcriptional regulation. This packaging is environment sensitive, yet its role in adaptation to novel environmental conditions is completely unknown. We set out to identify candidate chromatin-remodeling loci that are differentiated between tropical and temperate populations in Drosophila melanogaster, an ancestrally equatorial African species that has recently colonized temperate environments around the world. Here we describe sequence variation at seven such chromatin-remodeling loci, four of which (chd1, ssrp, chm, and glu) exhibit strong differentiation between tropical and temperate populations. An in-depth analysis of chm revealed sequence differentiation restricted to a small portion of the gene, as well as evidence of clinal variation along the east coasts of both the United States and Australia. The functions of chd1, chm, ssrp, and glu point to several novel hypotheses for the role of chromatin-based transcriptional regulation in adaptation to a novel environment. Specifically, both stress-induced transcription and developmental homeostasis emerge as potential functional targets of environment-dependent selection.

MeSH Terms
Adaptation, Biological/genetics Animals Base Sequence Chromatin Assembly and Disassembly/genetics Drosophila melanogaster/genetics Gene Expression Regulation/genetics Genetic Variation Genetics, Population Geography Linkage Disequilibrium Molecular Sequence Data Selection, Genetic Sequence Analysis, DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Levine Mia T
Center for Population Biology, University of California, Davis, CA 95616, USA. [email protected]
Begun David J
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.107.085423
Email
[email protected]
Published
2008-05-00
Epub
2008-00-03
Pages
475-85
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC2390624
Subset
IM
Grants
NIGMS NIH HHS · R01 GM071926 · United States
NIGMS NIH HHS · GM071926 · United States
External Links
PubMed source DOI: 10.1534/genetics.107.085423 PMC Full Text View journal details
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