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PMID: 18258121 Published · ppublish English Journal Article

Streptococcus pneumoniae serotype 19A in children, South Korea.

Emerging infectious diseases ·Vol. 14 ·No. 2 ·2008-02-00 ·Pages 275-81

Choi EH, Kim SH, Eun BW, Kim SJ, Kim NH, Lee J, Lee HJ

Abstract

Despite the concern of replacement disease, notably by serotype 19A after 7-valent conjugate vaccine (PCV7) use, serotype 19A was increasingly recognized in Korean children before the introduction of PCV7. To understand the dynamics of serogroup 19 prevalence from 1991-2006, we serotyped 538 pediatric pneumococcal isolates. Serogroup 19 isolates (n = 126) were characterized by antimicrobial drug susceptibility, presence of mefA/ermB, and multilocus sequence typing. Overall, the proportion of serotype 19A isolates increased but serotype 19F decreased. Among children <5 years of age, the proportion of serotype 19A isolates in invasive pneumococcal disease increased from 0% in 1991-1994 to 8%-10% in 1995-2000, reached 26% in 2001-2003, and remained at 20% in 2004-2006 when vaccine coverage did not exceed 25% (p = 0.005 for trend). This study demonstrates that the expansion of multidrug-resistant ST320 was responsible for the increase in serotype 19A before PCV7 use.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacterial Proteins/genetics Child Child, Preschool Drug Resistance, Multiple, Bacterial/genetics Humans Infant Infant, Newborn Korea/epidemiology Membrane Proteins/genetics Microbial Sensitivity Tests Pneumococcal Infections/epidemiology,microbiology Prevalence Serotyping Streptococcus pneumoniae/classification,drug effects,genetics,isolation & purification
Chemicals
Anti-Bacterial Agents Bacterial Proteins MefA protein, Streptococcus Membrane Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Choi Eun Hwa
Seoul National University College of Medicine, Seoul, South Korea.
Kim So Hee
Eun Byung Wook
Kim Sun Jung
Kim Nam Hee
Lee Jina
Lee Hoan Jong
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Article Info
Journal
Emerging infectious diseases
Abbr.
Emerg Infect Dis
ISSN
1080-6040
DOI
10.3201/eid1402.070807
Published
2008-02-00
Pages
275-81
Language
English
Region
United States
NLM ID
9508155
PMCID
PMC2600206
Subset
IM
External Links
PubMed source DOI: 10.3201/eid1402.070807 PMC Full Text View journal details
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