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PMID: 18264110 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.

Nature medicine ·Vol. 14 ·No. 3 ·2008-03-00 ·Pages 275-81

Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK

Abstract

Emerging evidence supports the concept that T helper type 17 (T(H)17) cells, in addition to mediating autoimmunity, have key roles in mucosal immunity against extracellular pathogens. Interleukin-22 (IL-22) and IL-17A are both effector cytokines produced by the T(H)17 lineage, and both were crucial for maintaining local control of the Gram-negative pulmonary pathogen, Klebsiella pneumoniae. Although both cytokines regulated CXC chemokines and granulocyte colony-stimulating factor production in the lung, only IL-22 increased lung epithelial cell proliferation and increased transepithelial resistance to injury. These data support the concept that the T(H)17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites.

MeSH Terms
Animals Cells, Cultured Chemokines/metabolism Cystic Fibrosis/immunology,pathology Epithelial Cells/metabolism Humans Immunity, Mucosal/immunology Interleukin-17/immunology Interleukin-23/immunology Interleukins/immunology,metabolism Klebsiella Infections/immunology Klebsiella pneumoniae/immunology,metabolism Lung/metabolism,microbiology Lymph Nodes/cytology Male Mice Mice, Inbred C57BL Neutralization Tests Receptors, Interleukin/genetics,metabolism Respiratory Mucosa/cytology Spleen/microbiology T-Lymphocytes/immunology Up-Regulation
Chemicals
Chemokines Interleukin-17 Interleukin-23 Interleukins Receptors, Interleukin interleukin-22 receptor interleukin-22
Authors & Affiliations
18 authors, click to expand affiliations / ORCID
Aujla Shean J
Children's Hospital of Pittsburgh, Suite 3765, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.
Chan Yvonne R
Zheng Mingquan
Fei Mingjian
Askew David J
Pociask Derek A
Reinhart Todd A
McAllister Florencia
Edeal Jennifer
Gaus Kristi
Husain Shahid
Kreindler James L
Dubin Patricia J
Pilewski Joseph M
Myerburg Mike M
Mason Carol A
Iwakura Yoichiro
Kolls Jay K
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Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1546-170X
DOI
10.1038/nm1710
Published
2008-03-00
Epub
2008-00-10
Pages
275-81
Language
English
Region
United States
NLM ID
9502015
PMCID
PMC2901867
Subset
IM
Grants
NHLBI NIH HHS · R37 HL079142 · United States
NHLBI NIH HHS · P50HL084932 · United States
NHLBI NIH HHS · R01 HL079142-04 · United States
NIDDK NIH HHS · P30 DK072506 · United States
NHLBI NIH HHS · R01 HL061271-04 · United States
NHLBI NIH HHS · P50 HL084932 · United States
NHLBI NIH HHS · R01 HL079142 · United States
NHLBI NIH HHS · 5R01HL079142 · United States
NHLBI NIH HHS · R01 HL061271 · United States
NCATS NIH HHS · UL1 TR000005 · United States
NIDDK NIH HHS · P30DK072506 · United States
Databases
GEO
GSE10240
Corrections
CommentIn
PMID: 18323844
External Links
PubMed source DOI: 10.1038/nm1710 PMC Full Text View journal details
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