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PMID: 1826672 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Reduced stimulation of helper T cells by Ki-ras transformed cells.

Immunology ·Vol. 72 ·No. 2 ·1991-02-00 ·Pages 277-81

Maudsley DJ, Bateman WJ, Morris AG

Abstract

A number of viral genes and cellular oncogenes inhibit major histocompatibility complex (MHC) antigen expression at the cell surface. In the case of inhibition of class I MHC antigens by viral genes this results in a reduced recognition by antigen-specific cytotoxic T cells. The activated Ki-ras cellular oncogene carried by the Ki-murine sarcoma virus (Ki-MuSV) in contrast inhibits class II MHC (or Ia) antigen expression on transformed cells. We have studied how transformation with Ki-ras affects recognition by alloreactive helper T cells. We found that the Ki-ras inhibition of class II MHC antigen expression led to greatly reduced stimulation of alloreactive T cells to proliferate and to secrete interferon-gamma (IFN-gamma). These findings support our hypothesis that the ability of an oncogene to reduce class II MHC antigen expression is crucial to its ability to produce tumour cells.

MeSH Terms
Animals Cell Division/immunology Cell Transformation, Viral/immunology Genes, ras/immunology Histocompatibility Antigens Class I/analysis Histocompatibility Antigens Class II/analysis Interferon-gamma/biosynthesis,immunology Male Mice Mice, Inbred BALB C Mice, Inbred C3H Recombinant Proteins Sarcoma, Experimental/immunology T-Lymphocytes, Helper-Inducer/immunology
Chemicals
Histocompatibility Antigens Class I Histocompatibility Antigens Class II Recombinant Proteins Interferon-gamma
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Maudsley D J
Department of Biological Sciences, University of Warwick, Coventry, U.K.
Bateman W J
Morris A G
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1991-02-00
Pages
277-81
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1384496
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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