T-cell receptor isoforms and signal transduction.

Current opinion in immunology ·Vol. 3 ·No. 1 ·1991-02-00 ·Pages 32-9

Koyasu S, D'Adamio L, Clayton LK, Reinherz EL

Abstract

Recent cDNA and genomic cloning have identified CD3 eta as an alternatively spliced product of the same gene locus that encodes CD3 zeta. Three distinct T-cell receptor isoforms have now been identified. A current view of the signal transduction function of these isoforms in thymocytes and T cells is discussed.

MeSH Terms

Antigens, Differentiation, T-Lymphocyte/biosynthesis,genetics CD3 Complex Calcium/metabolism Phosphatidylinositols/metabolism Protein Biosynthesis Protein-Tyrosine Kinases/metabolism RNA Processing, Post-Transcriptional Receptors, Antigen, T-Cell/biosynthesis,genetics,immunology Signal Transduction/immunology Transcription, Genetic

Chemicals

Antigens, Differentiation, T-Lymphocyte CD3 Complex Phosphatidylinositols Receptors, Antigen, T-Cell Protein-Tyrosine Kinases Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Koyasu S

Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

D'Adamio L

Clayton L K

Reinherz E L

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/0952-7915(91)90073-a

Published

1991-02-00

Pages

32-9

Language

English

Region

England

NLM ID

8900118

Subset

External Links

PubMed source DOI: 10.1016/0952-7915(91)90073-a View journal details

Analysis Services

T-cell receptor isoforms and signal transduction.

Contact

WeChat Official Account