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PMID: 18296645 Published · ppublish English Journal Article Research Support, N.I.H., Intramural

Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology ·Vol. 17 ·No. 3 ·2008-03-00 ·Pages 525-34

Andreotti G, Chen J, Gao YT, Rashid A, Chen BE, Rosenberg P, Sakoda LC, Deng J, Shen MC, Wang BS, Han TQ, Zhang BH, Yeager M, Welch R, Chanock S, Fraumeni JF, Hsing AW

Abstract

Biliary tract cancers, encompassing the gallbladder, extrahepatic bile duct, and ampulla of Vater, are uncommon yet highly fatal malignancies. Gallstones, the primary risk factor for biliary cancers, are linked with hyperlipidemia. We examined the associations of 12 single nucleotide polymorphisms of five genes in the lipid metabolism pathway with the risks of biliary cancers and stones in a population-based case-control study in Shanghai, China. We included 235 gallbladder, 125 extrahepatic bile duct, and 46 ampulla of Vater cancer cases, 880 biliary stone cases, and 779 population controls. Subjects completed an in-person interview and gave blood. Genotyping was conducted by TaqMan assay using DNA from buffy coats. The effects of APOE IVS1+69 (rs440446) and APOB IVS6+360C>T (rs520354) markers were limited to men. Men carrying the G allele of APOE IVS1+69 had a 1.7-fold risk of stones [95% confidence interval (95% CI), 1.2-2.4], a 1.8-fold risk of gallbladder cancer (95% CI, 1.0-3.3), a 3.7-fold risk of bile duct cancer (95% CI, 2.0-7.0), and a 4-fold risk of ampullary cancer (95% CI, 1.4-12.4). Male carriers of the T allele of APOB IVS6+360C>T had a 2-fold risk of bile duct cancer (95% CI, 1.2-3.4). The APOB T-T haplotype (APOB IVS6+360C>T, EX4+56C>T) was associated with a 1.6-fold risk of bile duct cancer (95% CI, 1.1-2.3). Male and female carriers of the T allele of LDLR IVS9-30C>T (rs1003723) had a 1.5-fold risk of bile duct cancer. Our findings suggest that gene variants in the lipid metabolism pathway contribute to the risk of biliary tract stones and cancers, particularly of the bile duct.

MeSH Terms
Adult Aged Alleles Biliary Tract Neoplasms/epidemiology,genetics Biomarkers, Tumor/analysis Case-Control Studies Chi-Square Distribution China/epidemiology Female Gallstones/epidemiology,genetics Genetic Variation Genotype Haplotypes Humans Interviews as Topic Lipid Metabolism Male Middle Aged Polymorphism, Single Nucleotide Regression Analysis Risk Factors Sex Factors
Chemicals
Biomarkers, Tumor
Authors & Affiliations
17 authors, click to expand affiliations / ORCID
Andreotti Gabriella
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 8011, MSC 7240, Bethesda, MD 20892, USA. [email protected]
Chen Jinbo
Gao Yu-Tang
Rashid Asif
Chen Bingshu E
Rosenberg Philip
Sakoda Lori C
Deng Jie
Shen Ming-Chang
Wang Bing-Sheng
Han Tian-Quan
Zhang Bai-He
Yeager Meredith
Welch Robert
Chanock Stephen
Fraumeni Joseph F
Hsing Ann W
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Article Info
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Abbr.
Cancer Epidemiol Biomarkers Prev
ISSN
1055-9965
DOI
10.1158/1055-9965.EPI-07-2704
Email
[email protected]
Published
2008-03-00
Epub
2008-00-22
Pages
525-34
Language
English
Region
United States
NLM ID
9200608
PMCID
PMC2897750
Subset
IM
Grants
Intramural NIH HHS · ZIA CP010158-09 · United States
External Links
PubMed source DOI: 10.1158/1055-9965.EPI-07-2704 PMC Full Text View journal details
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