Effect of anti-TNF treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis.

Clinical rheumatology ·Vol. 27 ·No. 6 ·2008-06-00 ·Pages 795-7

Serelis J, Kontogianni MD, Katsiougiannis S, Bletsa M, Tektonidou MG, Skopouli FN

Abstract

The aim of this study was to investigate the effect of anti-tumor necrosis factor alpha (anti-TNF) treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis (RA). Nineteen women with RA starting anti-TNF treatment were included in the study. Disease activity, body composition, lumbar spine bone mineral density (BMD) and serum adiponectin concentrations were measured at baseline and after 1 year of follow-up. No important changes on body composition and lumbar spine BMD were observed, while the serum levels of adiponectin levels increased after 1 year of anti-TNF treatment (p = 0.02). Anti-TNF treatment in women with RA does not have any significant effect on body composition; however, it is associated with increase in adiponectin levels which may ameliorate the systemic inflammatory response state associated with RA.

MeSH Terms

Adiponectin/blood Adult Aged Antibodies, Monoclonal/administration & dosage Antirheumatic Agents/administration & dosage Arthritis, Rheumatoid/drug therapy,immunology Body Composition/drug effects Bone Density/drug effects Drug Therapy, Combination Female Follow-Up Studies Humans Infliximab Methotrexate/administration & dosage Middle Aged Steroids/administration & dosage Tumor Necrosis Factor-alpha/antagonists & inhibitors

Chemicals

ADIPOQ protein, human Adiponectin Antibodies, Monoclonal Antirheumatic Agents Steroids Tumor Necrosis Factor-alpha Infliximab Methotrexate

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Serelis John

Department of Internal Medicine, Athens Euroclinic, 7 Athanasiadou Str, Athens 11521, Greece.

Kontogianni Meropi D

Katsiougiannis Stergios

Bletsa Maria

Tektonidou Maria G

Skopouli Fotini N

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Article Info

Journal

Clinical rheumatology

Abbr.

Clin Rheumatol

ISSN

0770-3198

DOI

10.1007/s10067-008-0855-7

Published

2008-06-00

Epub

2008-00-28

Pages

795-7

Language

English

Region

Germany

NLM ID

8211469

Subset

Corrections

CommentIn

PMID: 18651101

External Links

PubMed source DOI: 10.1007/s10067-008-0855-7 View journal details

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Effect of anti-TNF treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis.

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