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PMID: 18309086 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems.

Science (New York, N.Y.) ·Vol. 319 ·No. 5867 ·2008-02-29 ·Pages 1256-60

Cayirlioglu P, Kadow IG, Zhan X, Okamura K, Suh GS, Gunning D, Lai EC, Zipursky SL

Abstract

Carbon dioxide (CO2) elicits different olfactory behaviors across species. In Drosophila, neurons that detect CO2 are located in the antenna, form connections in a ventral glomerulus in the antennal lobe, and mediate avoidance. By contrast, in the mosquito these neurons are in the maxillary palps (MPs), connect to medial sites, and promote attraction. We found in Drosophila that loss of a microRNA, miR-279, leads to formation of CO2 neurons in the MPs. miR-279 acts through down-regulation of the transcription factor Nerfin-1. The ectopic neurons are hybrid cells. They express CO2 receptors and form connections characteristic of CO2 neurons, while exhibiting wiring and receptor characteristics of MP olfactory receptor neurons (ORNs). We propose that this hybrid ORN reveals a cellular intermediate in the evolution of species-specific behaviors elicited by CO2.

MeSH Terms
3' Untranslated Regions Animals Animals, Genetically Modified Carbon Dioxide/analysis,metabolism Drosophila/genetics,physiology Drosophila Proteins/genetics,metabolism Gene Expression Regulation Hybrid Cells/physiology MicroRNAs/genetics,metabolism Mutation Olfactory Receptor Neurons/cytology,physiology Receptors, Cell Surface/metabolism Sense Organs/physiology Species Specificity Transcription Factors/genetics,metabolism
Chemicals
3' Untranslated Regions Drosophila Proteins MicroRNAs Receptors, Cell Surface Transcription Factors carbon dioxide receptor nerfin-1 protein, Drosophila Carbon Dioxide
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Cayirlioglu Pelin
Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Kadow Ilona Grunwald
Zhan Xiaoli
Okamura Katsutomo
Suh Greg S B
Gunning Dorian
Lai Eric C
Zipursky S Lawrence
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1149483
Published
2008-02-29
Pages
1256-60
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2714168
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · R01 GM083300 · United States
NIDCD NIH HHS · DC006485 · United States
External Links
PubMed source DOI: 10.1126/science.1149483 PMC Full Text View journal details
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