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PMID: 18316025 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Stress-response hormesis and aging: "that which does not kill us makes us stronger".

Cell metabolism ·Vol. 7 ·No. 3 ·2008-03-00 ·Pages 200-3

Gems D, Partridge L

Abstract

Hormesis refers to the beneficial effects of a treatment that at a higher intensity is harmful. In one form of hormesis, sublethal exposure to stressors induces a response that results in stress resistance. The principle of stress-response hormesis is increasingly finding application in studies of aging, where hormetic increases in life span have been seen in several animal models.

MeSH Terms

Adaptation, Physiological Aging/metabolism Animals Biotransformation Caloric Restriction Dose-Response Relationship, Drug Environmental Pollutants/pharmacology,toxicity Humans Insulin/metabolism Insulin-Like Growth Factor I/metabolism Longevity/drug effects Signal Transduction/drug effects Stress, Physiological/chemically induced,metabolism,physiopathology

Chemicals

Environmental Pollutants Insulin Insulin-Like Growth Factor I

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Gems David

Institute of Healthy Ageing and Department of Genetics, Environment and Evolution, University College London, London WC1E 6BT, UK.

Partridge Linda

Article Info

Journal

Cell metabolism

Abbr.

Cell Metab

ISSN

1550-4131

DOI

10.1016/j.cmet.2008.01.001

Published

2008-03-00

Pages

200-3

Language

English

Region

United States

NLM ID

101233170

Subset

Grants

Wellcome Trust · 066750 · United Kingdom

External Links

PubMed source DOI: 10.1016/j.cmet.2008.01.001 View journal details

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Stress-response hormesis and aging: "that which does not kill us makes us stronger".

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