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PMID: 1832015 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping.

Biochimica et biophysica acta ·Vol. 1090 ·No. 1 ·1991-08-27 ·Pages 1-8

Tominaga S, Jenkins NA, Gilbert DJ, Copeland NG, Tetsuka T

Abstract

The genomic locus of the murine ST2 gene was isolated based on homology with a murine ST2 complementary DNA sequence and its complete nucleotide sequence was determined. The locus is composed of eight exons and seven introns and is approx. 9 kilobase pairs in size. Two Sp1 binding sites are present in the 5' flanking region. The murine ST2 gene, which was expressed only in the growth-stimulated BALB/c-3T3 cells, was mapped to mouse chromosome one, very tightly linked to the interleukin 1 receptor-type 1 locus.

Related Genes

ST2

MeSH Terms

Animals Base Sequence Blotting, Southern Cell Line Chromosome Mapping Cloning, Molecular Crosses, Genetic Exons/genetics Genes, Immunoglobulin Introns/genetics Mice Mice, Inbred BALB C Molecular Sequence Data Multigene Family/genetics Receptors, Immunologic/genetics Receptors, Interleukin-1 Sequence Homology, Nucleic Acid

Chemicals

Receptors, Immunologic Receptors, Interleukin-1

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Tominaga S

Department of Biochemistry II, Jichi Medical School, Tochigi, Japan.

Jenkins N A

Gilbert D J

Copeland N G

Tetsuka T

Article Info

Journal

Biochimica et biophysica acta

Abbr.

Biochim Biophys Acta

ISSN

0006-3002

DOI

10.1016/0167-4781(91)90029-l

Published

1991-08-27

Pages

1-8

Language

English

Region

Netherlands

NLM ID

0217513

Subset

Grants

NCI NIH HHS · N01-CO-74101 · United States

Databases

GENBANK

X60184

External Links

PubMed source DOI: 10.1016/0167-4781(91)90029-l

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Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping.

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