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PMID: 18340017 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Review

Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.

Circulation research ·Vol. 102 ·No. 5 ·2008-03-14 ·Pages 519-28

Ungvari Z, Parrado-Fernandez C, Csiszar A, de Cabo R

Abstract

This review focuses on the emerging evidence that attenuation of the production of reactive oxygen species and inhibition of inflammatory pathways play a central role in the antiaging cardiovascular effects of caloric restriction. Particular emphasis is placed on the potential role of the plasma membrane redox system in caloric restriction-induced pathways responsible for sensing oxidative stress and increasing cellular oxidative stress resistance. We propose that caloric restriction increases bioavailability of NO, decreases vascular reactive oxygen species generation, activates the Nrf2/antioxidant response element pathway, inducing reactive oxygen species detoxification systems, exerts antiinflammatory effects, and, thereby, suppresses initiation/progression of vascular disease that accompany aging.

MeSH Terms
Aging/metabolism Animals Caloric Restriction Cardiovascular System/metabolism Humans Life Expectancy Oxidative Stress/physiology Reactive Oxygen Species/metabolism Signal Transduction/physiology
Chemicals
Reactive Oxygen Species
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ungvari Zoltan
Department of Physiology, New York Medical College, Valhalla, USA.
Parrado-Fernandez Cristina
Csiszar Anna
de Cabo Rafael
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Article Info
Journal
Circulation research
Abbr.
Circ Res
ISSN
1524-4571
DOI
10.1161/CIRCRESAHA.107.168369
Published
2008-03-14
Pages
519-28
Language
English
Region
United States
NLM ID
0047103
PMCID
PMC2424221
Subset
IM
Grants
NHLBI NIH HHS · R01 HL077256 · United States
NHLBI NIH HHS · HL077256 · United States
NHLBI NIH HHS · P01 HL043023 · United States
NHLBI NIH HHS · HL43023 · United States
Intramural NIH HHS · Z01 AG000368-03 · United States
External Links
PubMed source DOI: 10.1161/CIRCRESAHA.107.168369 PMC Full Text View journal details
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