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PMID: 18362899 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Genetic factors influencing alcohol dependence.

British journal of pharmacology ·Vol. 154 ·No. 2 ·2008-05-00 ·Pages 275-87

Mayfield RD, Harris RA, Schuckit MA

Abstract

Plentiful data from both animal and human studies support the importance of genetic influences in substance abuse and dependence (Bierut et al., 1998; Tsuang et al., 1998; Kendler et al., 2003). This review summarizes the evidence supporting such genetic influences, places them into perspective regarding animal and human studies, discusses the importance of both genes and environment, and highlights some specific genes of interest regarding the vulnerabilities for problems associated with alcohol use disorders. A long history of repetitive heavy use of alcohol exists across generations as well as the high prevalence of alcohol-related problems in Western societies. Moreover, the information offered here addresses the importance of more general issues regarding genetics and gene expression related to alcohol abuse and dependence.

MeSH Terms
Alcoholism/genetics,metabolism,psychology Animals Autopsy Behavior, Addictive/genetics,metabolism Behavior, Animal Brain Chemistry/genetics Chromosome Mapping Gene Expression Profiling Gene Expression Regulation Genetic Predisposition to Disease Genotype Humans Models, Animal Phenotype RNA, Messenger/analysis Risk Factors
Chemicals
RNA, Messenger
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mayfield R D
Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA.
Harris R A
Schuckit M A
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1038/bjp.2008.88
Published
2008-05-00
Epub
2008-00-24
Pages
275-87
Language
English
Region
England
NLM ID
7502536
PMCID
PMC2442454
Subset
IM
Grants
NIAAA NIH HHS · R01 AA012404-08 · United States
NIAAA NIH HHS · 5R01AA005526 · United States
NIAAA NIH HHS · U01 AA016648 · United States
NIAAA NIH HHS · AA13518 · United States
NIAAA NIH HHS · 5 U10 AA008401 · United States
NIAAA NIH HHS · AA12404 · United States
NIAAA NIH HHS · AA016648 · United States
NIAAA NIH HHS · R01 AA005526 · United States
NIAAA NIH HHS · U01 AA013518 · United States
NIAAA NIH HHS · U01 AA013518-07 · United States
NIAAA NIH HHS · U10 AA008401 · United States
NIAAA NIH HHS · R01 AA012404 · United States
Corrections
CommentIn
PMID: 18414384
External Links
PubMed source DOI: 10.1038/bjp.2008.88 PMC Full Text View journal details
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