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PMID: 18369139 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Gene regulation in the third dimension.

Science (New York, N.Y.) ·Vol. 319 ·No. 5871 ·2008-03-28 ·Pages 1793-4

Dekker J

Abstract

Analysis of the spatial organization of chromosomes reveals complex three-dimensional networks of chromosomal interactions. These interactions affect gene expression at multiple levels, including long-range control by distant enhancers and repressors, coordinated expression of genes, and modification of epigenetic states. Major challenges now include deciphering the mechanisms by which loci come together and understanding the functional consequences of these often transient associations.

MeSH Terms
Animals Cell Nucleus/genetics,metabolism Chromosomes/genetics,metabolism Chromosomes, Human/genetics,metabolism Epigenesis, Genetic Gene Expression Regulation Humans Models, Genetic Regulatory Elements, Transcriptional Regulatory Sequences, Ribonucleic Acid
Chemicals
Regulatory Sequences, Ribonucleic Acid
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Dekker Job
Program in Gene Function and Expression and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605-0103, USA. [email protected]
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1152850
Email
[email protected]
Published
2008-03-28
Pages
1793-4
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2666883
Subset
IM
Grants
NHGRI NIH HHS · R01 HG003143 · United States
NHGRI NIH HHS · R01 HG003143-04 · United States
NHGRI NIH HHS · HG003143 · United States
External Links
PubMed source DOI: 10.1126/science.1152850 PMC Full Text View journal details
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