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PMID: 18400509 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis.

Cytokine ·Vol. 42 ·No. 3 ·2008-06-00 ·Pages 277-88

Panopoulos AD, Watowich SS

Abstract

Neutrophils are phagocytes whose principal function is to maintain anti-bacterial immunity. Neutrophils ingest and kill invading bacteria, releasing cytotoxic, chemotactic and inflammatory mediators at sites of infection. This serves to control the immediate host immune response and attract other cells, such as macrophages and dendritic cells, which are important for establishing long-term adaptive immunity. Neutrophils thus contribute to both the initiation and the maintenance of inflammation at sites of infection. Aberrant neutrophil activity is deleterious; suppressed responses can cause extreme susceptibility to infection while overactivation can lead to excessive inflammation and tissue damage. This review will focus on neutrophil regulation by granulocyte colony-stimulating factor (G-CSF), the principal cytokine controlling neutrophil development and function. The review will emphasize the molecular aspects of G-CSF-driven granulopoiesis in steady state (healthy) conditions and during demand-driven or 'emergency' conditions elicited by infection or clinical administration of G-CSF. Understanding the molecular control of granulopoiesis will aid in the development of new approaches designed to treat disorders of neutrophil production and function.

MeSH Terms
Animals Bacterial Infections/complications,immunology,physiopathology Cell Proliferation Gene Expression Regulation Granulocyte Colony-Stimulating Factor/pharmacology,physiology Humans Interleukin-17/physiology Mice Myelopoiesis/physiology Neutropenia/etiology,immunology,physiopathology Neutrophil Activation/physiology Receptors, Granulocyte Colony-Stimulating Factor/physiology Signal Transduction
Chemicals
Interleukin-17 Receptors, Granulocyte Colony-Stimulating Factor Granulocyte Colony-Stimulating Factor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Panopoulos Athanasia D
Department of Immunology and Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, PO Box 301402, Unit 902, Houston, TX 77030, USA.
Watowich Stephanie S
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Article Info
Journal
Cytokine
Abbr.
Cytokine
ISSN
1096-0023
DOI
10.1016/j.cyto.2008.03.002
Published
2008-06-00
Epub
2008-00-08
Pages
277-88
Language
English
Region
England
NLM ID
9005353
PMCID
PMC2852428
Subset
IM
Grants
NCI NIH HHS · T32 CA009598 · United States
NCI NIH HHS · T32-CA-09598-16 · United States
NCI NIH HHS · R01 CA077447-03 · United States
NCI NIH HHS · R01 CA077447-02 · United States
NCI NIH HHS · CA77447 · United States
External Links
PubMed source DOI: 10.1016/j.cyto.2008.03.002 PMC Full Text View journal details
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