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PMID: 18404475 Published · ppublish English Journal Article

Physiological roles for ecto-5'-nucleotidase (CD73).

Purinergic signalling ·Vol. 2 ·No. 2 ·2006-06-00 ·Pages 351-60

Colgan SP, Eltzschig HK, Eckle T, Thompson LF

Abstract

Nucleotides and nucleosides influence nearly every aspect of physiology and pathophysiology. Extracellular nucleotides are metabolized through regulated phosphohydrolysis by a series of ecto-nucleotidases. The formation of extracellular adenosine from adenosine 5'-monophosphate is accomplished primarily through ecto-5'-nucleotidase (CD73), a glycosyl phosphatidylinositol-linked membrane protein found on the surface of a variety of cell types. Recent in vivo studies implicating CD73 in a number of tissue protective mechanisms have provided new insight into its regulation and function and have generated considerable interest. Here, we review contributions of CD73 to cell and tissue stress responses, with a particular emphasis on physiologic responses to regulated CD73 expression and function, as well as new findings utilizing Cd73-deficient animals.

Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Colgan Sean P
Center for Experimental Therapeutics, Brigham and Women’s Hospital, Harvard Medical School, Thorn Building 704, 75 Francis Street, Boston, Massachusetts, 02115, USA, [email protected].
Eltzschig Holger K
Eckle Tobias
Thompson Linda F
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Article Info
Journal
Purinergic signalling
Abbr.
Purinergic Signal
ISSN
1573-9538
DOI
10.1007/s11302-005-5302-5
Email
[email protected]
Published
2006-06-00
Epub
2006-00-01
Pages
351-60
Language
English
Region
Netherlands
NLM ID
101250499
PMCID
PMC2254482
Grants
NIAID NIH HHS · R01 AI018220 · United States
NIDCR NIH HHS · P01 DE013499 · United States
NIDDK NIH HHS · R29 DK050189 · United States
NIDDK NIH HHS · R37 DK050189 · United States
NHLBI NIH HHS · R01 HL060569 · United States
NIDDK NIH HHS · R01 DK050189 · United States
External Links
PubMed source DOI: 10.1007/s11302-005-5302-5 PMC Full Text View journal details
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