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PMID: 18411419 Published · ppublish English Clinical Trial, Phase II Journal Article

Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab.

Blood ·Vol. 111 ·No. 12 ·2008-06-15 ·Pages 5530-6

Khouri IF, McLaughlin P, Saliba RM, Hosing C, Korbling M, Lee MS, Medeiros LJ, Fayad L, Samaniego F, Alousi A, Anderlini P, Couriel D, de Lima M, Giralt S, Neelapu SS, Ueno NT, Samuels BI, Hagemeister F, Kwak LW, Champlin RE

Abstract

Nonmyeloablative stem cell transplantation in patients with follicular lymphoma has been designed to exploit the graft-versus-lymphoma immunity. The long-term effectiveness and toxicity of this strategy, however, is unknown. In this prospective study, we analyzed our 8-year experience. Patients received a conditioning regimen of fludarabine (30 mg/m(2) daily for 3 days), cyclophosphamide (750 mg/m(2) daily for 3 days), and rituximab (375 mg/m(2) for 1 day plus 1000 mg/m(2) for 3 days). They were then given an infusion of human leukocyte antigen-matched hematopoietic cells from related (n = 45) or unrelated donors (n = 2). Tacrolimus and methotrexate were used for graft-versus-host disease (GVHD) prophylaxis. Forty-seven patients were included. All patients experienced complete remission, with only 2 relapses. With a median follow-up time of 60 months (range, 19-94), the estimated survival and progression-free survival rates were 85% and 83%, respectively. All 18 patients who were tested and had evidence of JH/bcl-2 fusion transcripts in the bone marrow at study entry experienced continuous molecular remission. The incidence of grade 2-IV acute GVHD was 11%. Only 5 patients were still undergoing immunosuppressive therapy at the time of last follow-up. We believe that the described results are a step forward toward developing a curative strategy for recurrent follicular lymphoma.

MeSH Terms
Adult Aged Antibodies, Monoclonal/administration & dosage,adverse effects Antibodies, Monoclonal, Murine-Derived Antineoplastic Agents/administration & dosage,adverse effects B-Lymphocytes/cytology Combined Modality Therapy Cyclophosphamide/administration & dosage,adverse effects Female Follow-Up Studies Graft vs Host Disease Graft vs Tumor Effect Hematopoietic Stem Cell Transplantation Humans Lymphoma, Follicular/drug therapy Male Middle Aged Myeloablative Agonists/administration & dosage,adverse effects Prospective Studies Recurrence Remission Induction Rituximab Survival Rate Transplantation Chimera Transplantation Conditioning/methods Transplantation, Homologous Vidarabine/administration & dosage,adverse effects,analogs & derivatives
Chemicals
Antibodies, Monoclonal Antibodies, Monoclonal, Murine-Derived Antineoplastic Agents Myeloablative Agonists Rituximab Cyclophosphamide Vidarabine fludarabine
Authors & Affiliations
20 authors, click to expand affiliations / ORCID
Khouri Issa F
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA. [email protected]
McLaughlin Peter
Saliba Rima M
Hosing Chitra
Korbling Martin
Lee Ming S
Medeiros L Jeffrey
Fayad Luis
Samaniego Felipe
Alousi Amin
Anderlini Paolo
Couriel Daniel
de Lima Marcos
Giralt Sergio
Neelapu Sattva S
Ueno Naoto T
Samuels Barry I
Hagemeister Fredrick
Kwak Larry W
Champlin Richard E
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Article Info
Journal
Blood
Abbr.
Blood
ISSN
1528-0020
Published
2008-06-15
Epub
2008-00-14
Pages
5530-6
Language
English
Region
United States
NLM ID
7603509
PMCID
PMC4624452
Subset
IM
Corrections
ErratumIn
-
CommentIn
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