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PMID: 18460347 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Endothelial cell regulation by phospholipid oxidation products.

Free radical biology & medicine ·Vol. 45 ·No. 2 ·2008-07-15 ·Pages 119-23

Berliner JA, Gharavi NM

Abstract

Oxidized phospholipids accumulate in atherosclerotic lesions, on lipoproteins, in other states of chronic inflammation, on apoptotic cells, necrotic cells and cells exposed to oxidative stress. These lipids regulate the transcription of over 1000 gene, regulating many endothelial functions, by activating several different cell surface receptors and multiple signaling pathways. These lipids also have important effects not involving transcription that regulate cell junctions and leukocyte binding. Thus these lipids are potent regulators of endothelial cell function with broad effects comparable in extent but differing from those of cytokines.

MeSH Terms
Animals Endothelial Cells/metabolism Endothelium, Vascular/physiology Gene Expression Regulation Humans Inflammation/metabolism Oxidation-Reduction Phospholipids/metabolism Signal Transduction/physiology
Chemicals
Phospholipids
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Berliner Judith A
Department of Pathology, University of California at Los Angeles 13-229 CHS, Pathology, 650 Charles Young Dr. South, Los Angeles, CA 90095, USA. [email protected]
Gharavi Nima M
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Article Info
Journal
Free radical biology & medicine
Abbr.
Free Radic Biol Med
ISSN
0891-5849
DOI
10.1016/j.freeradbiomed.2008.04.013
Email
[email protected]
Published
2008-07-15
Epub
2008-00-20
Pages
119-23
Language
English
Region
United States
NLM ID
8709159
PMCID
PMC2895487
Subset
IM
Grants
NHLBI NIH HHS · P01 HL030568-230006 · United States
NHLBI NIH HHS · R01 HL064731 · United States
NHLBI NIH HHS · R01 HL064731-08 · United States
NHLBI NIH HHS · P01 HL30568 · United States
NHLBI NIH HHS · R01 HL 064731 · United States
NHLBI NIH HHS · P01 HL030568 · United States
External Links
PubMed source DOI: 10.1016/j.freeradbiomed.2008.04.013 PMC Full Text View journal details
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