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PMID: 18466323 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease.

Journal of neurochemistry ·Vol. 106 ·No. 4 ·2008-08-00 ·Pages 1503-14

Pasinetti GM, Eberstein JA

Abstract

Since Alzheimer's disease (AD) has no cure or preventive treatment, an urgent need exists to find a means of preventing, delaying the onset, or reversing the course of the disease. Clinical and epidemiological evidence suggests that lifestyle factors, especially nutrition, may be crucial in controlling AD. Unhealthy lifestyle choices lead to an increasing incidence of obesity, dyslipidemia and hypertension--components of the metabolic syndrome. These disorders can also be linked to AD. Recent research supports the hypothesis that calorie intake, among other non-genetic factors, can influence the risk of clinical dementia. In animal studies, high calorie intake in the form of saturated fat promoted AD-type amyloidosis, while calorie restriction via reduced carbohydrate intake prevented it. Pending further study, it is prudent to recommend to those at risk for AD--e.g. with a family history or features of metabolic syndrome, such as obesity, insulin insensitivity, etc.--to avoid foods and beverages with added sugars; to eat whole, unrefined foods with natural fats, especially fish, nuts and seeds, olives and olive oil; and to minimize foods that disrupt insulin and blood sugar balance.

MeSH Terms
Alzheimer Disease/diet therapy,etiology,prevention & control Animals Diet/adverse effects Humans Life Style Metabolic Syndrome/complications,diet therapy
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pasinetti Giulio Maria
Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer's Disease, Department of Psychiatry, The Mount Sinai School of Medicine, New York, New York, USA. [email protected]
Eberstein Jacqueline A
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Article Info
Journal
Journal of neurochemistry
Abbr.
J Neurochem
ISSN
1471-4159
DOI
10.1111/j.1471-4159.2008.05454.x
Email
[email protected]
Published
2008-08-00
Epub
2008-00-03
Pages
1503-14
Language
English
Region
England
NLM ID
2985190R
PMCID
PMC2587074
Subset
IM
Grants
NIA NIH HHS · P01 AG002219 · United States
NIA NIH HHS · P01 AG002219-280010 · United States
NIA NIH HHS · AG02219 · United States
External Links
PubMed source DOI: 10.1111/j.1471-4159.2008.05454.x PMC Full Text View journal details
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