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PMID: 1847108 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Hepatocyte swelling increases inositol 1,4,5-trisphosphate, calcium and cyclic AMP concentration but antagonizes phosphorylase activation by Ca2(+)-dependent hormones.

FEBS letters ·Vol. 278 ·No. 1 ·1991-01-14 ·Pages 103-6

Baquet A, Meijer AJ, Hue L

Abstract

Swelling of hepatocytes increases the concentration of inositol 1,4,5-trisphosphate, Ca2+ and cAMP, without activating glycogen phosphorylase. In these hepatocytes, the activation of phosphorylase by suboptimal concentrations of vasopressin or angiotensin II was partly antagonized.

MeSH Terms

Animals Calcium/metabolism Cyclic AMP/metabolism Enzyme Activation Glutamine/pharmacology Glycogen Synthase/metabolism Inositol 1,4,5-Trisphosphate/metabolism Liver/drug effects,enzymology,pathology Phosphorylases/antagonists & inhibitors,metabolism Rats Vasopressins/pharmacology

Chemicals

Glutamine Vasopressins Inositol 1,4,5-Trisphosphate Cyclic AMP Phosphorylases Glycogen Synthase Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Baquet A

Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium.

Meijer A J

Hue L

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(91)80094-j

Published

1991-01-14

Pages

103-6

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(91)80094-j View journal details

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Hepatocyte swelling increases inositol 1,4,5-trisphosphate, calcium and cyclic AMP concentration but antagonizes phosphorylase activation by Ca2(+)-dependent hormones.

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