Home LiteratureArticle Details

PMID: 1848685 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.

Nature ·Vol. 350 ·No. 6315 ·1991-03-21 ·Pages 207-11

Acha-Orbea H, Shakhov AN, Scarpellino L, Kolb E, Müller V, Vessaz-Shaw A, Fuchs R, Blöchlinger K, Rollini P, Billotte J

Abstract

Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.

MeSH Terms

Amino Acid Sequence Animals Chromosome Deletion Electrophoresis, Polyacrylamide Gel Female Genes, Viral Mammary Tumor Virus, Mouse/genetics Mice Mice, Transgenic Molecular Sequence Data Open Reading Frames Phenotype Proviruses/genetics Receptors, Antigen, T-Cell/genetics T-Lymphocytes/immunology

Chemicals

Receptors, Antigen, T-Cell

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Acha-Orbea H

Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.

Shakhov A N

Scarpellino L

Kolb E

Müller V

Vessaz-Shaw A

Fuchs R

Blöchlinger K

Rollini P

Billotte J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/350207a0

Published

1991-03-21

Pages

207-11

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/350207a0 View journal details

Analysis Services

Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.

Contact

WeChat Official Account