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PMID: 1851798 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Induction of autoreactive B cells allows priming of autoreactive T cells.

The Journal of experimental medicine ·Vol. 173 ·No. 6 ·1991-06-01 ·Pages 1433-9

Lin RH, Mamula MJ, Hardin JA, Janeway CA

Abstract

A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen.

MeSH Terms
Animals Antibody Formation Antigen-Presenting Cells/immunology Autoimmunity/immunology B-Lymphocytes/immunology Cytochrome c Group/immunology Histocompatibility Antigens Class II/immunology Immune Tolerance Lymphocyte Activation Mice Mice, Inbred Strains T-Lymphocytes/immunology
Chemicals
Cytochrome c Group Histocompatibility Antigens Class II
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lin R H
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Mamula M J
Hardin J A
Janeway C A
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.173.6.1433
Published
1991-06-01
Pages
1433-9
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2190847
Subset
IM
Grants
NIAID NIH HHS · AI-26810 · United States
NIAMS NIH HHS · AR-32549 · United States
External Links
PubMed source DOI: 10.1084/jem.173.6.1433 PMC Full Text View journal details
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