Epithelial-mesenchymal transition and the stem cell phenotype.

Cell stem cell ·Vol. 2 ·No. 6 ·2008-06-05 ·Pages 511-2

Radisky DC, LaBarge MA

Abstract

Epithelial-mesenchymal transition (EMT) is a developmental process in which epithelial cells acquire the motile, migratory properties of mesenchymal cells. In a recent issue of Cell, Mani et al. (2008) show that induction of EMT stimulates cultured breast cells to adopt characteristics of stem cells.

MeSH Terms

Animals Biomarkers, Tumor Breast Neoplasms/pathology CD24 Antigen/metabolism Cell Movement Cell Transdifferentiation Cell Transformation, Neoplastic Epithelial Cells/cytology Female Humans Hyaluronan Receptors/metabolism Mesenchymal Stem Cells/cytology Mesoderm/cytology,physiology Neoplasm Invasiveness Neoplastic Stem Cells/metabolism,pathology Tumor Cells, Cultured

Chemicals

Biomarkers, Tumor CD24 Antigen Hyaluronan Receptors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Radisky Derek C

Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA. [email protected]

LaBarge Mark A

Article Info

Journal

Cell stem cell

Abbr.

Cell Stem Cell

ISSN

1875-9777

DOI

10.1016/j.stem.2008.05.007

[email protected]

Published

2008-06-05

Pages

511-2

Language

English

Region

United States

NLM ID

101311472

Subset

Grants

NCI NIH HHS · R01 CA122086 · United States

Corrections

CommentOn

PMID: 18485877

External Links

PubMed source DOI: 10.1016/j.stem.2008.05.007 View journal details

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