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PMID: 185291 Published · ppublish English Journal Article

Natural infection with influenza A (H3N2). The development, persistance and effect of antibodies to the surface antigens.

The Journal of hygiene ·Vol. 77 ·No. 2 ·1976-10-00 ·Pages 271-82

Smith AJ, Davies JR

Abstract

A technique for estimating antibodies to the neuraminidase antigens of influenza A is described. The antibody response to the haemagglutinin and neuraminidase antigens of influenza A (H3N2) was studied in a boys' public school over the four-year period 1970--4. During this time there were two outbreaks of influenza A and the effect of antibody on the result of natural challenge was investigated. No boy who had homotypic neuraminidase antibody had clinical influenza.

MeSH Terms
Adolescent Antibodies, Viral/analysis Antigens, Viral Cell Membrane/immunology Child Disease Outbreaks England Hemagglutination Inhibition Tests Humans Influenza A Virus, H3N2 Subtype Influenza A virus/enzymology,immunology Influenza Vaccines/administration & dosage Male Neuraminidase/immunology Orthomyxoviridae Infections/epidemiology,immunology
Chemicals
Antibodies, Viral Antigens, Viral Influenza Vaccines Neuraminidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Smith A J
Davies J R
References (7)
7 references, click to expand
  1. Influenza at Christ's Hospital: March, 1974.
    Lancet. 1976 Jan 17;1(7951):105-8 PMID: 54631
  2. Antiantibody enhancement of hemagglutination inhibition by influenza anti-neuraminidase.
    J Immunol. 1972 Dec;109(6):1321-6 PMID: 4538965
  3. Influenzavirus neuraminidase and neuraminidase-inhibition test procedures.
    Bull World Health Organ. 1973;48(2):199-202 PMID: 4541685
  4. Association of serum anti-neuraminidase antibody with resistance to influenza in man.
    N Engl J Med. 1972 Jun 22;286(25):1329-32 PMID: 5027388
  5. A quantitative, single-radial-diffusion test for immunological studies with influenza virus.
    J Gen Virol. 1972 Aug;16(2):231-6 PMID: 4627327
  6. Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines.
    J Hyg (Lond). 1971 Dec;69(4):571-8 PMID: 5002644
  7. Induction of partial immunity to influenza by a neuraminidase-specific vaccine.
    J Infect Dis. 1974 Apr;129(4):411-20 PMID: 4593871
Article Info
Journal
The Journal of hygiene
Abbr.
J Hyg (Lond)
ISSN
0022-1724
Published
1976-10-00
Pages
271-82
Language
English
Region
England
NLM ID
0375374
PMCID
PMC2129857
Subset
IM
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