Abstract
A technique for estimating antibodies to the neuraminidase antigens of influenza A is described. The antibody response to the haemagglutinin and neuraminidase antigens of influenza A (H3N2) was studied in a boys' public school over the four-year period 1970--4. During this time there were two outbreaks of influenza A and the effect of antibody on the result of natural challenge was investigated. No boy who had homotypic neuraminidase antibody had clinical influenza.
MeSH Terms
Adolescent
Antibodies, Viral/analysis
Antigens, Viral
Cell Membrane/immunology
Child
Disease Outbreaks
England
Hemagglutination Inhibition Tests
Humans
Influenza A Virus, H3N2 Subtype
Influenza A virus/enzymology,immunology
Influenza Vaccines/administration & dosage
Male
Neuraminidase/immunology
Orthomyxoviridae Infections/epidemiology,immunology
Chemicals
Antibodies, Viral
Antigens, Viral
Influenza Vaccines
Neuraminidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Smith A J
Davies J R
References (7)
7 references, click to expand
-
Influenza at Christ's Hospital: March, 1974.
Lancet. 1976 Jan 17;1(7951):105-8
PMID: 54631
-
Antiantibody enhancement of hemagglutination inhibition by influenza anti-neuraminidase.
J Immunol. 1972 Dec;109(6):1321-6
PMID: 4538965
-
Influenzavirus neuraminidase and neuraminidase-inhibition test procedures.
Bull World Health Organ. 1973;48(2):199-202
PMID: 4541685
-
Association of serum anti-neuraminidase antibody with resistance to influenza in man.
N Engl J Med. 1972 Jun 22;286(25):1329-32
PMID: 5027388
-
A quantitative, single-radial-diffusion test for immunological studies with influenza virus.
J Gen Virol. 1972 Aug;16(2):231-6
PMID: 4627327
-
Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines.
J Hyg (Lond). 1971 Dec;69(4):571-8
PMID: 5002644
-
Induction of partial immunity to influenza by a neuraminidase-specific vaccine.
J Infect Dis. 1974 Apr;129(4):411-20
PMID: 4593871