Home LiteratureArticle Details
PMID: 18539967 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Gastric cancer stem cells.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology ·Vol. 26 ·No. 17 ·2008-06-10 ·Pages 2876-82

Takaishi S, Okumura T, Wang TC

Abstract

Cancer stem cells are defined as the unique subpopulation in the tumors that possess the ability to initiate tumor growth and sustain self-renewal as well as metastatic potential. Accumulating evidence in recent years strongly indicate the existence of cancer stem cells in solid tumors of a wide variety of organs. In this review, we will discuss the possible existence of a gastric cancer stem cell. Our recent data suggest that a subpopulation with a defined marker shows spheroid colony formation in serum-free media in vitro, as well as tumorigenic ability in immunodeficient mice in vivo. We will also discuss the possible origins of the gastric cancer stem cell from an organ-specific stem cell versus a recently recognized new candidate bone marrow-derived cell (BMDC). We have previously shown that BMDC contributed to malignant epithelial cells in the mouse model of Helicobacter-associated gastric cancer. On the basis of these findings from animal model, we propose that a similar phenomenon may also occur in human cancer biology, particularly in the cancer origin of other inflammation-associated cancers. The expanding research field of cancer stem-cell biology may offer a novel clinical apparatus to the diagnosis and treatment of cancer.

MeSH Terms
Animals Bone Marrow Cells/pathology Cell Differentiation Cell Proliferation Cell Transformation, Neoplastic/pathology Helicobacter Infections/complications,pathology Humans Inflammation/complications,pathology Mice Neoplastic Stem Cells/pathology Risk Factors Stomach Neoplasms/etiology,pathology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Takaishi Shigeo
Division of Digestive and Liver Disease, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Okumura Tomoyuki
Wang Timothy C
References (69)
69 references, click to expand
  1. Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers.
    World J Gastroenterol. 2006 Jan 21;12(3):363-71 PMID: 16489634
  2. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.
    Nat Med. 1997 Jul;3(7):730-7 PMID: 9212098
  3. Tumor growth need not be driven by rare cancer stem cells.
    Science. 2007 Jul 20;317(5836):337 PMID: 17641192
  4. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis.
    Nature. 2007 Oct 4;449(7162):557-63 PMID: 17914389
  5. Stem cells, cancer, and cancer stem cells.
    Nature. 2001 Nov 1;414(6859):105-11 PMID: 11689955
  6. Bone marrow-derived cells fuse with normal and transformed intestinal stem cells.
    Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6321-5 PMID: 16606845
  7. Pathology of mouse models of intestinal cancer: consensus report and recommendations.
    Gastroenterology. 2003 Mar;124(3):762-77 PMID: 12612914
  8. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.
    Nature. 2006 Dec 7;444(7120):756-60 PMID: 17051156
  9. Helicobacter pylori infection and the development of gastric cancer.
    N Engl J Med. 2001 Sep 13;345(11):784-9 PMID: 11556297
  10. Hereditary diffuse gastric cancer: diagnosis and management.
    Clin Gastroenterol Hepatol. 2006 Mar;4(3):262-75 PMID: 16527687
  11. Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity.
    J Natl Cancer Inst. 2006 Oct 18;98(20):1445-52 PMID: 17047193
  12. Providing AID to p53 mutagenesis.
    Nat Med. 2007 Apr;13(4):404-6 PMID: 17415370
  13. Gastric cancer originating from bone marrow-derived cells.
    Science. 2004 Nov 26;306(5701):1568-71 PMID: 15567866
  14. Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners.
    J Clin Invest. 2004 May;113(9):1266-70 PMID: 15124017
  15. Phenotypic characterization of human colorectal cancer stem cells.
    Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63 PMID: 17548814
  16. Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue.
    Curr Opin Hematol. 2006 May;13(3):175-81 PMID: 16567962
  17. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion.
    Cell. 2005 May 6;121(3):335-48 PMID: 15882617
  18. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts.
    Cancer Res. 2004 Dec 1;64(23):8492-5 PMID: 15574751
  19. A cytokine-mediated link between innate immunity, inflammation, and cancer.
    J Clin Invest. 2007 May;117(5):1175-83 PMID: 17476347
  20. Helicobacter pylori and gastrointestinal tract adenocarcinomas.
    Nat Rev Cancer. 2002 Jan;2(1):28-37 PMID: 11902583
  21. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.
    Nature. 2006 Dec 7;444(7120):761-5 PMID: 17151667
  22. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell.
    Cell. 2001 May 4;105(3):369-77 PMID: 11348593
  23. Focus on gastric cancer.
    Cancer Cell. 2004 Feb;5(2):121-5 PMID: 14998488
  24. Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver.
    Hepatology. 2000 Dec;32(6):1230-9 PMID: 11093729
  25. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species.
    Nat Med. 1997 Dec;3(12):1337-45 PMID: 9396603
  26. Prospective identification of tumorigenic breast cancer cells.
    Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 PMID: 12629218
  27. Identification of a cancer stem cell in human brain tumors.
    Cancer Res. 2003 Sep 15;63(18):5821-8 PMID: 14522905
  28. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.
    Nat Med. 2007 Apr;13(4):470-6 PMID: 17401375
  29. Identification and expansion of human colon-cancer-initiating cells.
    Nature. 2007 Jan 4;445(7123):111-5 PMID: 17122771
  30. Dynamic histology of the antral epithelium in the mouse stomach: I. Architecture of antral units.
    Am J Anat. 1985 Mar;172(3):187-204 PMID: 3887885
  31. Modelling breast cancer: one size does not fit all.
    Nat Rev Cancer. 2007 Sep;7(9):659-72 PMID: 17721431
  32. Inflammation, atrophy, and gastric cancer.
    J Clin Invest. 2007 Jan;117(1):60-9 PMID: 17200707
  33. Identification and characterization of tumorigenic liver cancer stem/progenitor cells.
    Gastroenterology. 2007 Jun;132(7):2542-56 PMID: 17570225
  34. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell.
    Science. 1996 Jul 12;273(5272):242-5 PMID: 8662508
  35. Prospective identification of a multilineage progenitor in murine stomach epithelium.
    Gastroenterology. 2007 Dec;133(6):1989-98 PMID: 18054570
  36. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization.
    FASEB J. 2006 Jul;20(9):1495-7 PMID: 16754748
  37. Dynamic histology of the antral epithelium in the mouse stomach: III. Ultrastructure and renewal of pit cells.
    Am J Anat. 1985 Mar;172(3):225-40 PMID: 3993598
  38. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma.
    Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):973-8 PMID: 17210912
  39. Prospective identification of tumorigenic prostate cancer stem cells.
    Cancer Res. 2005 Dec 1;65(23):10946-51 PMID: 16322242
  40. Prevalence of Helicobacter pylori infection in subtypes of gastric cancer.
    Gastroenterology. 1995 Sep;109(3):885-8 PMID: 7657118
  41. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice.
    Gastroenterology. 2005 Jun;128(7):1937-52 PMID: 15940628
  42. Stem cell biology of the central nervous system.
    J Neurosci Res. 2002 Sep 15;69(6):698-707 PMID: 12205662
  43. A tumorigenic subpopulation with stem cell properties in melanomas.
    Cancer Res. 2005 Oct 15;65(20):9328-37 PMID: 16230395
  44. Molecular biology. Cancer's perpetual source?
    Science. 2007 Aug 24;317(5841):1029-31 PMID: 17717165
  45. Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers.
    Gastroenterology. 2005 May;128(6):1567-78 PMID: 15887152
  46. Brain tumour stem cells.
    Nat Rev Cancer. 2006 Jun;6(6):425-36 PMID: 16723989
  47. Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection.
    Gastroenterology. 1998 Apr;114(4):675-89 PMID: 9516388
  48. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer.
    Cell Stem Cell. 2007 Sep 13;1(3):313-23 PMID: 18371365
  49. Dynamic histology of the antral epithelium in the mouse stomach: IV. Ultrastructure and renewal of gland cells.
    Am J Anat. 1985 Mar;172(3):241-59 PMID: 3993599
  50. Carcinogenesis of Helicobacter pylori.
    Gastroenterology. 2007 Aug;133(2):659-72 PMID: 17681184
  51. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.
    Nature. 1994 Feb 17;367(6464):645-8 PMID: 7509044
  52. Cancer: stem cells and brain tumours.
    Nature. 2006 Dec 7;444(7120):687-8 PMID: 17151644
  53. Identification of stem cells in small intestine and colon by marker gene Lgr5.
    Nature. 2007 Oct 25;449(7165):1003-7 PMID: 17934449
  54. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
    Cancer Res. 2006 Oct 1;66(19):9339-44 PMID: 16990346
  55. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes.
    Nature. 2003 Oct 30;425(6961):968-73 PMID: 14555960
  56. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice.
    Nature. 2007 Jan 4;445(7123):106-10 PMID: 17122772
  57. Stem cells and cancer.
    Semin Cancer Biol. 2007 Jun;17(3):191-203 PMID: 16762563
  58. Evidence that fibroblasts derive from epithelium during tissue fibrosis.
    J Clin Invest. 2002 Aug;110(3):341-50 PMID: 12163453
  59. Donor-derived human bone marrow cells contribute to solid organ cancers developing after bone marrow transplantation.
    Stem Cells. 2007 Nov;25(11):2903-9 PMID: 17690178
  60. Epstein-Barr virus and gastric carcinoma.
    Mol Pathol. 2000 Oct;53(5):255-61 PMID: 11091849
  61. Identification of pancreatic cancer stem cells.
    Cancer Res. 2007 Feb 1;67(3):1030-7 PMID: 17283135
  62. Dynamic histology of the antral epithelium in the mouse stomach: II. Ultrastructure and renewal of isthmal cells.
    Am J Anat. 1985 Mar;172(3):205-24 PMID: 3993597
  63. Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract.
    Nat Med. 2002 Sep;8(9):1011-7 PMID: 12195435
  64. Transplanted bone marrow regenerates liver by cell fusion.
    Nature. 2003 Apr 24;422(6934):901-4 PMID: 12665833
  65. The biology of cancer stem cells.
    Annu Rev Cell Dev Biol. 2007;23:675-99 PMID: 17645413
  66. Helicobacter pylori and gastric carcinogenesis.
    Am J Surg Pathol. 1995;19 Suppl 1:S37-43 PMID: 7762738
  67. Chemokines direct endothelial progenitors into tumor neovessels.
    Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18111-6 PMID: 16326806
  68. Multipotential stem cells in adult mouse gastric epithelium.
    Am J Physiol Gastrointest Liver Physiol. 2002 Sep;283(3):G767-77 PMID: 12181193
  69. Cell fusion is the principal source of bone-marrow-derived hepatocytes.
    Nature. 2003 Apr 24;422(6934):897-901 PMID: 12665832
Article Info
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Abbr.
J Clin Oncol
ISSN
1527-7755
DOI
10.1200/JCO.2007.15.2603
Published
2008-06-10
Pages
2876-82
Language
English
Region
United States
NLM ID
8309333
PMCID
PMC2743304
Subset
IM
Grants
NCI NIH HHS · R01 CA093405 · United States
NCI NIH HHS · R01 CA120979 · United States
NCI NIH HHS · R01 CA120979-02 · United States
External Links
PubMed source DOI: 10.1200/JCO.2007.15.2603 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2