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PMID: 18607713 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Genome scan of a nonword repetition phenotype in families with dyslexia: evidence for multiple loci.

Behavior genetics ·Vol. 38 ·No. 5 ·2008-09-00 ·Pages 462-75

Brkanac Z, Chapman NH, Igo RP, Matsushita MM, Nielsen K, Berninger VW, Wijsman EM, Raskind WH

Abstract

To understand the genetic architecture of dyslexia and identify the locations of genes involved, we performed linkage analyses in multigenerational families using a phonological memory phenotype--Nonword Repetition (NWR). A genome scan was first performed on 438 people from 51 families (DS-1) and linkage was assessed using variance components (VC), Bayesian oligogenic (BO), and parametric analyses. For replication, the genome scan and analyses were repeated on 693 people from 93 families (DS-2). For the combined set (DS-C), analyses were performed with all three methods in the regions that were identified in both samples. In DS-1, regions on chromosomes 4p, 6q, 12p, 17q, and 22q exceeded our initial threshold for linkage, with 17q providing a parametric LOD score of 3.2. Analysis with DS-2 confirmed the locations on chromosomes 4p and 12p. The strongest VC and BO signals in both samples were on chromosome 4p in DS-C, with a parametric multipoint LOD(max) of 2.36 for the 4p locus. Our linkage analyses of NWR in dyslexia provide suggestive and reproducible evidence for linkage to 4p12 and 12p in both samples, and significant evidence for linkage to 17q in one of the samples. These results warrant further studies of phonological memory and chromosomal regions identified here in other datasets.

MeSH Terms
Adult Child Dyslexia/genetics Family Health Female Genetic Linkage Genetic Predisposition to Disease Genome Genotype Humans Male Memory Middle Aged Parents Phenotype
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Brkanac Zoran
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195-6560, USA. [email protected]
Chapman Nicola H
Igo Robert P
Matsushita Mark M
Nielsen Kathleen
Berninger Virginia W
Wijsman Ellen M
Raskind Wendy H
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Article Info
Journal
Behavior genetics
Abbr.
Behav Genet
ISSN
1573-3297
DOI
10.1007/s10519-008-9215-2
Email
[email protected]
Published
2008-09-00
Epub
2008-00-08
Pages
462-75
Language
English
Region
United States
NLM ID
0251711
PMCID
PMC2853749
Subset
IM
Grants
NIGMS NIH HHS · R01 GM046255-15 · United States
NCRR NIH HHS · 1P41 RR03655 · United States
NCRR NIH HHS · P41 RR003655 · United States
NCRR NIH HHS · P41 RR003655-17A1 · United States
NIGMS NIH HHS · R01 GM046255 · United States
NICHD NIH HHS · P50 HD33812 · United States
NHLBI NIH HHS · N01-HV-48141 · United States
NICHD NIH HHS · R01 HD054562-02 · United States
NICHD NIH HHS · K08 HD049342 · United States
NHLBI NIH HHS · N01HV48141 · United States
NIGMS NIH HHS · R01 GM46255 · United States
NICHD NIH HHS · R01 HD054562 · United States
NICHD NIH HHS · K08 HD049342-05 · United States
NICHD NIH HHS · P50 HD033812 · United States
NICHD NIH HHS · P50 HD033812-09 · United States
External Links
PubMed source DOI: 10.1007/s10519-008-9215-2 PMC Full Text View journal details
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