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PMID: 18617886 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Impact of MHC class I diversity on immune control of immunodeficiency virus replication.

Nature reviews. Immunology ·Vol. 8 ·No. 8 ·2008-08-00 ·Pages 619-30

Goulder PJ, Watkins DI

Abstract

The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. The well-described association between the expression of particular MHC class I molecules and successful containment of HIV or, in the macaque model, SIV replication provide a valuable starting point from which to evaluate more precisely what might constitute effective CD8(+) T-cell responses. Here, we review recent studies of T-cell-mediated control of HIV and SIV infection, and offer insight for the design of a successful T-cell-based HIV vaccine in the future.

MeSH Terms
AIDS Vaccines/immunology Animals CD8-Positive T-Lymphocytes/immunology,virology HIV Infections/immunology,prevention & control,virology HIV-1/immunology,physiology Histocompatibility Antigens Class I/immunology Humans Macaca mulatta SAIDS Vaccines/immunology Simian Acquired Immunodeficiency Syndrome/immunology,prevention & control,virology Simian Immunodeficiency Virus/immunology,physiology Virus Replication/immunology
Chemicals
AIDS Vaccines Histocompatibility Antigens Class I SAIDS Vaccines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goulder Philip J R
Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK. [email protected]
Watkins David I
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2357
Email
[email protected]
Published
2008-08-00
Pages
619-30
Language
English
Region
England
NLM ID
101124169
PMCID
PMC2963026
Subset
IM
Grants
PHS HHS · HHSN266200400088C · United States
NIAID NIH HHS · R01 AI052056 · United States
NCRR NIH HHS · R24 RR015371-12 · United States
NCRR NIH HHS · R24 RR016038 · United States
NCRR NIH HHS · R24 RR016038-11 · United States
NIAID NIH HHS · R01 AI049120-09 · United States
NIAID NIH HHS · R21 AI077472-02 · United States
NIAID NIH HHS · R01 AI046995 · United States
NIAID NIH HHS · R21 AI077472 · United States
NIAID NIH HHS · R01 AI076114-05 · United States
NIAID NIH HHS · R01 AI052056-05 · United States
NIAID NIH HHS · R01 AI46995 · United States
NCRR NIH HHS · R24 RR015371 · United States
NIAID NIH HHS · R01 AI076117 · United States
NIAID NIH HHS · R01 AI076114 · United States
NIAID NIH HHS · R01 AI049120 · United States
External Links
PubMed source DOI: 10.1038/nri2357 PMC Full Text View journal details
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