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PMID: 18663128 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.

The Journal of experimental medicine ·Vol. 205 ·No. 8 ·2008-08-04 ·Pages 1903-16

Cosmi L, De Palma R, Santarlasci V, Maggi L, Capone M, Frosali F, Rodolico G, Querci V, Abbate G, Angeli R, Berrino L, Fambrini M, Caproni M, Tonelli F, Lazzeri E, Parronchi P, Liotta F, Maggi E, Romagnani S, Annunziato F

Abstract

We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17-producing cells are contained in the CD161(+) fraction of CD4(+) T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural killer T cells. More importantly, we show that all IL-17-producing cells originate from CD161(+) naive CD4(+) T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the combined activity of IL-1 beta and IL-23. These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor.

MeSH Terms
Adult Antigens, Surface/genetics,metabolism CD4-Positive T-Lymphocytes/cytology,immunology Case-Control Studies Cell Differentiation Crohn Disease/genetics,immunology Fetal Blood/cytology,immunology Hematopoietic Stem Cells/cytology,immunology Humans Infant, Newborn Inflammation/genetics,immunology,pathology Interleukin-17/biosynthesis Lectins, C-Type/genetics,metabolism NK Cell Lectin-Like Receptor Subfamily B Nuclear Receptor Subfamily 1, Group F, Member 3 Psoriasis/genetics,immunology RNA, Messenger/genetics,metabolism Receptors, Interleukin/genetics Receptors, Retinoic Acid/genetics Receptors, Thyroid Hormone/genetics T-Lymphocyte Subsets/cytology,immunology Th1 Cells/cytology,immunology Th2 Cells/cytology,immunology Thymus Gland/cytology,immunology Up-Regulation
Chemicals
Antigens, Surface IL23R protein, human Interleukin-17 KLRB1 protein, human Lectins, C-Type NK Cell Lectin-Like Receptor Subfamily B Nuclear Receptor Subfamily 1, Group F, Member 3 RNA, Messenger RORC protein, human Receptors, Interleukin Receptors, Retinoic Acid Receptors, Thyroid Hormone
Authors & Affiliations
20 authors, click to expand affiliations / ORCID
Cosmi Lorenzo
Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy.
De Palma Raffaele
Santarlasci Veronica
Maggi Laura
Capone Manuela
Frosali Francesca
Rodolico Gabriella
Querci Valentina
Abbate Gianfranco
Angeli Roberta
Berrino Liberato
Fambrini Massimiliano
Caproni Marzia
Tonelli Francesco
Lazzeri Elena
Parronchi Paola
Liotta Francesco
Maggi Enrico
Romagnani Sergio
Annunziato Francesco
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
1540-9538
DOI
10.1084/jem.20080397
Published
2008-08-04
Epub
2008-00-28
Pages
1903-16
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2525581
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.20080397 PMC Full Text View journal details
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