Fattening up without overeating.

Cell metabolism ·Vol. 8 ·No. 2 ·2008-08-00 ·Pages 95-6

Watts JL

Abstract

When food becomes scarce, animals undergo distinct metabolic, behavioral, and physiological changes that allow them to survive. In this issue, Greer et al. (2008) take advantage of the relatively simple and well-characterized nervous system of C. elegans to elucidate a neural circuit regulating feeding behavior and fat storage.

MeSH Terms

Adipose Tissue/physiology Animals Appetite Regulation/physiology Behavior, Animal/physiology Caenorhabditis elegans/physiology Energy Metabolism/physiology Movement/physiology Nervous System/metabolism Starvation/metabolism Transforming Growth Factor beta/metabolism

Chemicals

Transforming Growth Factor beta

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Watts Jennifer L

School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA. [email protected]

References (6)

6 references, click to expand

Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety.
Cell Metab. 2008 Mar;7(3):249-57 PMID: 18316030
Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms.
Cell Metab. 2008 Jun;7(6):533-44 PMID: 18522834
TGF-beta signaling.
WormBook. 2005 Sep 09;:1-12 PMID: 18050404
Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.
Cell Metab. 2008 Aug;8(2):118-31 PMID: 18680713
A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49.
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13496-501 PMID: 16157872
The comparative physiology of food deprivation: from feast to famine.
Annu Rev Physiol. 2006;68:223-51 PMID: 16460272

Article Info

Journal

Cell metabolism

Abbr.

Cell Metab

ISSN

1932-7420

DOI

10.1016/j.cmet.2008.07.003

[email protected]

Published

2008-08-00

Pages

95-6

Language

English

Region

United States

NLM ID

101233170

PMCID

PMC2601642

Subset

Grants

NIDDK NIH HHS · R01 DK074114 · United States

NIDDK NIH HHS · R01 DK074114-03 · United States

Corrections

CommentOn

PMID: 18680713

External Links

PubMed source DOI: 10.1016/j.cmet.2008.07.003 PMC Full Text View journal details

Analysis Services

Fattening up without overeating.

Contact

WeChat Official Account