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PMID: 18682804 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

Generation of breast cancer stem cells through epithelial-mesenchymal transition.

PloS one ·Vol. 3 ·No. 8 ·2008-08-06 ·Pages e2888

Morel AP, Lièvre M, Thomas C, Hinkal G, Ansieau S, Puisieux A

Abstract

Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells" in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of "cancer stem cells" can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway. The acquisition of these stem and tumorigenic characters is driven by EMT induction.

MeSH Terms
Breast/cytology Breast Neoplasms/pathology,virology CD24 Antigen/analysis,genetics Cell Division Colony-Forming Units Assay Epithelial Cells/cytology,pathology,virology Female Flow Cytometry Humans Hyaluronan Receptors/analysis Mesoderm/pathology Neoplasm Metastasis Retroviridae Stem Cells/cytology,pathology,virology Tumor Cells, Cultured
Chemicals
CD24 Antigen Hyaluronan Receptors
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Morel Anne-Pierre
Centre Léon Bérard, Lyon, France.
Lièvre Marjory
Thomas Clémence
Hinkal George
Ansieau Stéphane
Puisieux Alain
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Article Info
Journal
PloS one
Abbr.
PLoS One
ISSN
1932-6203
DOI
10.1371/journal.pone.0002888
Published
2008-08-06
Epub
2008-00-06
Pages
e2888
Language
English
Region
United States
NLM ID
101285081
PMCID
PMC2492808
Subset
IM
External Links
PubMed source DOI: 10.1371/journal.pone.0002888 PMC Full Text View journal details
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