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PMID: 18697994 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The Na-K-ATPase and calcium-signaling microdomains.

Physiology (Bethesda, Md.) ·Vol. 23 ·2008-08-00 ·Pages 205-11

Tian J, Xie ZJ

Abstract

The Na-K-ATPase is an energy-transducing ion pump that converts the free energy of ATP into transmembrane ion gradients. It also serves as a functional receptor for cardiotonic steroids such as ouabain and digoxin. Binding of ouabain to the Na-K-ATPase can activate calcium signaling in a cell-specific manner. The exquisite calcium modulation via the Na-K-ATPase is achieved by the ability of the pump to integrate signals from numerous protein and non-protein molecules, including ion transporters, channels, protein kinases/phosphatases, as well as cellular Na+. This review focuses on the unique properties of the Na-K-ATPase and its role in the formation of different calcium-signaling microdomains.

MeSH Terms
Animals Calcium Signaling/physiology Cell Compartmentation/physiology Epithelial Cells/enzymology Humans Sodium-Potassium-Exchanging ATPase/metabolism
Chemicals
Sodium-Potassium-Exchanging ATPase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tian Jiang
Department of Physiology and Pharmacology, University of Toledo Health Science Campus, Toledo, Ohio, USA.
Xie Zi-jian
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Article Info
Journal
Physiology (Bethesda, Md.)
Abbr.
Physiology (Bethesda)
ISSN
1548-9213
DOI
10.1152/physiol.00008.2008
Published
2008-08-00
Pages
205-11
Language
English
Region
United States
NLM ID
101208185
PMCID
PMC5375021
Subset
IM
Grants
NIGMS NIH HHS · R01 GM078565-02 · United States
NHLBI NIH HHS · R01 HL067963 · United States
NHLBI NIH HHS · P01 HL036573-200011 · United States
NHLBI NIH HHS · R01 HL067963-05 · United States
NHLBI NIH HHS · HL-36573 · United States
NHLBI NIH HHS · P01 HL036573 · United States
NHLBI NIH HHS · HL-67963 · United States
NIGMS NIH HHS · GM-78565 · United States
NIGMS NIH HHS · R01 GM078565 · United States
External Links
PubMed source DOI: 10.1152/physiol.00008.2008 PMC Full Text View journal details
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