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PMID: 187331 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.

Cancer research ·Vol. 37 ·No. 1 ·1977-01-00 ·Pages 172-81

Swenson DH, Lin JK, Miller EC, Miller JA

Abstract

Administration of[3H]aflatoxin B2 (2,3-dihydroaflatoxin B1)(AFB2) to male rats resulted in levels of hepatic DNA- and ribosomal(r)RNA-aflatoxin adducts that were about 1% of those for rats given [3H]aflatoxin B1(AFB1). The levels of hepatic protein-aflatoxin adducts were 35 to 70% as great for AFB2-treated as compared to AFB1-treated rats...

MeSH Terms

Aflatoxins/metabolism,toxicity Animals Carcinogens Carcinoma, Hepatocellular/chemically induced DNA/metabolism Intestine, Small/metabolism Kidney/metabolism Liver/metabolism Liver Neoplasms/chemically induced Male Neoplasms, Experimental/chemically induced Oxides/metabolism Phenobarbital/pharmacology Pituitary Gland/physiology Protein Binding RNA, Ribosomal/metabolism Rats Spleen/metabolism

Chemicals

Aflatoxins Carcinogens Oxides RNA, Ribosomal DNA Phenobarbital

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Swenson D H

Lin J K

Miller E C

Miller J A

Article Info

Journal

Cancer research

Abbr.

Cancer Res

ISSN

0008-5472

Published

1977-01-00

Pages

172-81

Language

English

Region

United States

NLM ID

2984705R

Subset

External Links

PubMed source View journal details

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Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.

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