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PMID: 18786659 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Mechanics of airflow in the human nasal airways.

Respiratory physiology & neurobiology ·Vol. 163 ·No. 1-3 ·2008-11-30 ·Pages 100-10

Doorly DJ, Taylor DJ, Schroter RC

Abstract

The mechanics of airflow in the human nasal airways is reviewed, drawing on the findings of experimental and computational model studies. Modelling inevitably requires simplifications and assumptions, particularly given the complexity of the nasal airways. The processes entailed in modelling the nasal airways (from defining the model, to its production and, finally, validating the results) is critically examined, both for physical models and for computational simulations. Uncertainty still surrounds the appropriateness of the various assumptions made in modelling, particularly with regard to the nature of flow. New results are presented in which high-speed particle image velocimetry (PIV) and direct numerical simulation are applied to investigate the development of flow instability in the nasal cavity. These illustrate some of the improved capabilities afforded by technological developments for future model studies. The need for further improvements in characterising airway geometry and flow together with promising new methods are briefly discussed.

MeSH Terms
Computer Simulation Humans Mechanics Models, Biological Nasal Cavity/physiology Pulmonary Ventilation
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Doorly D J
Department of Aeronautics, Imperial College London, Exhibition Road, London SW7 2AZ, UK. [email protected]
Taylor D J
Schroter R C
Article Info
Journal
Respiratory physiology & neurobiology
Abbr.
Respir Physiol Neurobiol
ISSN
1569-9048
Published
2008-11-30
Epub
2008-00-14
Pages
100-10
Language
English
Region
Netherlands
NLM ID
101140022
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · BB/E023444/1 · United Kingdom
Biotechnology and Biological Sciences Research Council · BB/E023441/1 · United Kingdom
Biotechnology and Biological Sciences Research Council · E18557 · United Kingdom
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