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PMID: 18791238 Published · ppublish English Journal Article

Controlling type-I error of the McDonald-Kreitman test in genomewide scans for selection on noncoding DNA.

Genetics ·Vol. 180 ·No. 3 ·2008-11-00 ·Pages 1767-71

Andolfatto P

Abstract

Departures from the assumption of homogenously interdigitated neutral and putatively selected sites in the McDonald-Kreitman test can lead to false rejections of the neutral model in the presence of intermediate levels of recombination. This problem is exacerbated by small sample sizes, nonequilibrium demography, recombination rate variation, and in comparisons involving more recently diverged species. I propose that establishing significance levels by coalescent simulation with recombination can improve the fidelity of the test in genomewide scans for selection on noncoding DNA.

MeSH Terms
Animals DNA, Intergenic/genetics Drosophila/genetics Genetic Linkage Genome, Insect Models, Genetic Recombination, Genetic Selection, Genetic
Chemicals
DNA, Intergenic
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Andolfatto Peter
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA. [email protected]
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.108.091850
Email
[email protected]
Published
2008-11-00
Epub
2008-00-14
Pages
1767-71
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC2581974
Subset
IM
External Links
PubMed source DOI: 10.1534/genetics.108.091850 PMC Full Text View journal details
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