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PMID: 188017 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A model for replication of the ends of linear chromosomes.

Nucleic acids research ·Vol. 3 ·No. 11 ·1976-11-00 ·Pages 3167-71

Heumann JM

Abstract

Linear chromosomes possessing internal repeats of their terminal sequences can form intramolecular crossed-strand exchanges that allow replication of the chromosome ends. Evidence is discussed that such a mechanism may be utilized during replication of herpes simplex virus DNA and during replication of macronuclear DNA from the hypotrichous ciliate Oxytricha.

MeSH Terms
Animals Chromosomes/metabolism Ciliophora/metabolism DNA Replication DNA, Viral/metabolism DNA-Directed DNA Polymerase/metabolism Models, Biological Simplexvirus/metabolism
Chemicals
DNA, Viral DNA-Directed DNA Polymerase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Heumann J M
References (12)
12 references, click to expand
  1. Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short components.
    Proc Natl Acad Sci U S A. 1975 Nov;72(11):4243-7 PMID: 172900
  2. Anatomy of herpes simplex virus DNA. V. Terminally repetitive sequences.
    J Virol. 1976 Feb;17(2):503-12 PMID: 176427
  3. Palindromic base sequences and replication of eukaryote chromosome ends.
    Nature. 1974 Aug 9;250(5466):467-70 PMID: 4469597
  4. Origin of concatemeric T7 DNA.
    Nat New Biol. 1972 Oct 18;239(94):197-201 PMID: 4507727
  5. Genetic recombination: the nature of a crossed strand-exchange between two homologous DNA molecules.
    J Mol Biol. 1972 Nov 28;71(3):789-93 PMID: 4648347
  6. Thermodynamic and kinetic studies on the interconversion between the linear and circular forms of phage lambda DNA.
    J Mol Biol. 1966 Jan;15(1):111-23 PMID: 5912035
  7. Inverted repetitious sequences in the macronuclear DNA of hypotrichous ciliates.
    Proc Natl Acad Sci U S A. 1975 Feb;72(2):678-82 PMID: 804696
  8. DNA of ciliated protozoa: DNA sequence diminution during macronuclear development of Oxytricha.
    Cell. 1976 Jan;7(1):67-74 PMID: 820431
  9. DNA replication.
    Annu Rev Biochem. 1975;44:45-78 PMID: 1094915
  10. The recent excitement in the DNA growing point problem.
    Annu Rev Microbiol. 1975;29:525-59 PMID: 1180524
  11. Anatomy of herpes simplex virus DNA. II. Size, composition, and arrangement of inverted terminal repetitions.
    J Virol. 1975 Jun;15(6):1487-97 PMID: 167196
  12. Inverted repetitions in the chromosome of herpes simplex virus.
    Cold Spring Harb Symp Quant Biol. 1975;39 Pt 2:667-78 PMID: 169022
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/3.11.3167
Published
1976-11-00
Pages
3167-71
Language
English
Region
England
NLM ID
0411011
PMCID
PMC343160
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/3.11.3167 PMC Full Text View journal details
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